Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VEGFA | P15692 | 7/20 | 0.57 |
| ▸ | EGLN1 | Q9GZT9 | 7/20 | 0.57 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.44 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.44 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.44 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.44 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.44 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.44 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.44 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.44 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.44 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.44 |
| ▸ | CACNG1 | Q06432 | 1/20 | 0.44 |
| ▸ | CACNB2 | Q08289 | 1/20 | 0.44 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.44 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.44 |
| ▸ | CACNA1E | Q15878 | 1/20 | 0.44 |
| ▸ | CACNA2D4 | Q7Z3S7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17340697 | 0.92 | VEGFA (0.67) | VEGFAEGLN1ALDH1A1SIGMAR1 | |
| SCHEMBL17340662 | 0.89 | VEGFA (0.49) | VEGFAEGLN1TSHRL3MBTL1ALDH1A1 | |
| SCHEMBL17340685 | 0.83 | EGLN1 (0.50) | VEGFAEGLN1ALDH1A1MAPK14 | |
| SCHEMBL273696 | 0.82 | EGLN1 (0.85) | VEGFAEGLN1CACNB4CACNA1ACACNA1G | |
| SCHEMBL277668 | 0.82 | EGLN1 (0.85) | VEGFAEGLN1CACNB4CACNA1ACACNA1G | |
| SCHEMBL271963 | 0.82 | EGLN1 (0.85) | VEGFAEGLN1CACNB4CACNA1ACACNA1G | |
| SCHEMBL273037 | 0.80 | EGLN1 (0.87) | VEGFAEGLN1CACNB4CACNA1ACACNA1G | |
| SCHEMBL15314777 | 0.77 | CNR2 (0.42) | VEGFAEGLN1ALDH1A1MAPK14 | |
| SCHEMBL15314769 | 0.73 | VEGFA (0.46) | VEGFAEGLN1CXCR4ALDH1A1 | |
| SCHEMBL17340673 | 0.73 | EGLN1 (0.71) | VEGFAEGLN1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2954899-A1 | COMPOSITIONS AND METHODS FOR TREATING COLITIS | Aerpio Therapeutics, Inc. (US) | 2015-12-16 | — | — | EP | disclosed |