SCHEMBL15315922

SCHEMBL15315922

CC(C)(C)OC(=O)CN1CCN(C(=O)OC(C)(C)C)CC1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 1/20 0.55
CHRM4 P08173 1/20 0.55
CHRM1 P11229 1/20 0.55
CHRM3 P20309 1/20 0.55
USP2 O75604 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
TERT O14746 1/20 0.45
HPGD P15428 1/20 0.44
EPHX2 P34913 1/20 0.43
ALDH1A1 P00352 3/20 0.43
VEGFA P15692 1/20 0.43
EGLN1 Q9GZT9 1/20 0.43
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
DTYMK P23919 1/20 0.42
RECQL P46063 1/20 0.42
EPHX1 P07099 1/20 0.42
MAPT P10636 2/20 0.42
NPC1 O15118 1/20 0.42
MAPK1 P28482 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13992916 0.91 CHRM3 (0.48) CHRM2CHRM4CHRM1CHRM3USP2
SCHEMBL4360565 0.90 CHRM2 (0.52) CHRM2CHRM4CHRM1CHRM3USP2
SCHEMBL27147241 0.89 PLA2G10 (0.41) CHRM2CHRM4CHRM1CHRM3USP2
SCHEMBL3799622 0.89 PLA2G10 (0.41) CHRM2CHRM4CHRM1CHRM3USP2
SCHEMBL3470166 0.89 PLA2G10 (0.41) CHRM2CHRM4CHRM1CHRM3USP2
SCHEMBL13992909 0.88 CHRM2 (0.46) CHRM2CHRM4CHRM1CHRM3USP2
SCHEMBL26090256 0.87 CHRM2 (0.50) CHRM2CHRM4CHRM1CHRM3USP2
SCHEMBL6219928 0.87 CHRM2 (0.50) CHRM2CHRM4CHRM1CHRM3USP2
SCHEMBL1088524 0.87 CHRM2 (0.50) CHRM2CHRM4CHRM1CHRM3USP2
SCHEMBL578032 0.86 CHRM2 (0.55) CHRM2CHRM4CHRM1CHRM3USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024217537-A1 TERTIARY AMINE COMPOUND AS WELL AS PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF 深圳信立泰药业股份有限公司 2024-10-24 WO disclosed
US-20240216513-A1 FATTY ACID-BIFUNCTIONAL DEGRADER CONJUGATES AND THEIR METHODS OF USE NOVARTIS AG (CH) 2024-07-04 US disclosed
US-20240216513-A1 FATTY ACID-BIFUNCTIONAL DEGRADER CONJUGATES AND THEIR METHODS OF USE NOVARTIS AG (CH) 2024-07-04 US disclosed
CN-112313207-B Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof 北京赛特明强医药科技有限公司 2023-02-14 CN disclosed
CN-109311880-B Novel tetrahydropyridopyrimidines for the treatment and prophylaxis of hepatitis B virus infections 豪夫迈·罗氏有限公司 2021-09-03 CN disclosed
CN-112313207-A Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof 北京赛特明强医药科技有限公司 2021-02-02 CN disclosed
EP-3478680-B1 NOVEL TETRAHYDROPYRIDOPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HBV INFECTION HOFFMANN LA ROCHE (CH) 2020-04-22 EP disclosed
EP-3478680-B1 NOVEL TETRAHYDROPYRIDOPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HBV INFECTION HOFFMANN LA ROCHE (CH) 2020-04-22 EP disclosed
WO-2019242689-A1 CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF 北京赛特明强医药科技有限公司 2019-12-26 WO disclosed
WO-2019242689-A1 CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF 北京赛特明强医药科技有限公司 2019-12-26 WO disclosed
US-20190241559-A1 NOVEL TETRAHYDROPYRIDOPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HBV INFECTION HOFFMANN-LA ROCHE INC. (US) 2019-08-08 US disclosed
US-20190241559-A1 NOVEL TETRAHYDROPYRIDOPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HBV INFECTION HOFFMANN-LA ROCHE INC. (US) 2019-08-08 US disclosed
WO-2019118612-A1 TARGETING COMPOUNDS ZAFGEN, INC. (US) 2019-06-20 WO disclosed
WO-2019118612-A1 TARGETING COMPOUNDS ZAFGEN, INC. (US) 2019-06-20 WO disclosed
EP-2712863-B1 Novel inhibitors of bacterial biofilms and related methods SEQUOIA SCIENCES INC (US) 2014-10-22 EP disclosed
US-20130274256-A1 NOVEL INHIBITORS OF BACTERIAL BIOFILMS AND RELATED METHODS SEQUOIA SCIENCES, INC. (US) 2013-10-17 US disclosed
US-20130274256-A1 NOVEL INHIBITORS OF BACTERIAL BIOFILMS AND RELATED METHODS SEQUOIA SCIENCES, INC. (US) 2013-10-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240216513-A1 FATTY ACID-BIFUNCTIONAL DEGRADER CONJUGATES AND THEIR METHODS OF USE FASN, FABP1, SCD CHRM2 4807/4885CHRM4 4838/4885CHRM1 4827/4885
US-20190241559-A1 NOVEL TETRAHYDROPYRIDOPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HBV INFECTION TYMP, RECQL, DPYD CHRM2 3673/4885CHRM4 4086/4885CHRM1 2866/4885
US-20130274256-A1 NOVEL INHIBITORS OF BACTERIAL BIOFILMS AND RELATED METHODS BLVRB, MMP8, PGLS CHRM2 4788/4885CHRM4 4733/4885CHRM1 4735/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.