Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 4/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5867880 | 0.85 | EPHX1 (0.48) | EPHX1SMN1; SMN2ALDH1A1KMT2ALMNA | |
| SCHEMBL5868447 | 0.80 | ALDH1A1 (0.50) | EPHX1ALDH1A1KDM4E | |
| SCHEMBL23845320 | 0.78 | EPHX1 (0.57) | EPHX1SMN1; SMN2EPHX2ALDH1A1KMT2A | |
| SCHEMBL901540 | 0.78 | EPHX1 (0.57) | EPHX1SMN1; SMN2EPHX2ALDH1A1KMT2A | |
| SCHEMBL22393075 | 0.78 | EPHX1 (0.57) | EPHX1SMN1; SMN2EPHX2ALDH1A1KMT2A | |
| SCHEMBL901572 | 0.78 | EPHX1 (0.57) | EPHX1SMN1; SMN2EPHX2ALDH1A1KMT2A | |
| SCHEMBL8393668 | 0.78 | NPC1 (0.73) | EPHX1SMN1; SMN2EPHX2ALDH1A1KMT2A | |
| SCHEMBL8395990 | 0.78 | NPC1 (0.73) | EPHX1SMN1; SMN2EPHX2ALDH1A1KMT2A | |
| SCHEMBL23431981 | 0.78 | EPHX1 (1.00) | EPHX1SMN1; SMN2EPHX2ALDH1A1KMT2A | |
| SCHEMBL23432014 | 0.78 | EPHX1 (1.00) | EPHX1SMN1; SMN2EPHX2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2485589-A1 | HETEROARYL BTK INHIBITORS | Biogen Idec MA Inc. (US) | 2012-08-15 | — | — | EP | disclosed |
| WO-2011029043-A1 | HETEROARYL BTK INHIBITORS | BIOGEN IDEC MA INC. (US) | 2011-03-10 | — | — | WO | disclosed |