Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 5/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL251035 | 0.87 | KDM4E (0.53) | PTPN11ALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL12914313 | 0.83 | PTPN11 (0.50) | PTPN11ALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL28827251 | 0.79 | KDM4E (0.61) | PTPN11ALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL30987378 | 0.79 | PTPN11 (0.47) | PTPN11ALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL27646939 | 0.77 | GUSB (0.49) | PTPN11ALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL27639574 | 0.76 | GUSB (0.48) | PTPN11ALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL17819129 | 0.76 | ALOX15 (0.54) | PTPN11ALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL27620753 | 0.76 | GUSB (0.51) | PTPN11ALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL968101 | 0.76 | KDM4E (0.61) | ALDH1A1HPGDKDM4EHSD17B10DCTPP1 | |
| SCHEMBL1107963 | 0.75 | KDM4E (0.47) | PTPN11ALDH1A1HPGDKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011028651-A1 | INHIBITORS OF HUMAN 15-LIPOXYGENASE-1 | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-03-10 | — | — | WO | disclosed |
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |