Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | NPC1 | O15118 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALPL | P05186 | 1/20 | 0.52 |
| ▸ | ALPI | P09923 | 1/20 | 0.52 |
| ▸ | ALPG | P10696 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | CASP7 | P55210 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL251035 | 0.84 | KDM4E (0.53) | ALOX15KDM4EALDH1A1NPC1MAPT | |
| SCHEMBL12914313 | 0.80 | PTPN11 (0.50) | ALOX15KDM4EALDH1A1NPC1MAPT | |
| SCHEMBL1531740 | 0.76 | PTPN11 (0.47) | ALOX15KDM4EALDH1A1NPC1MAPT | |
| SCHEMBL28827251 | 0.76 | KDM4E (0.61) | KDM4EALDH1A1NPC1MAPTRAB9A | |
| SCHEMBL30987378 | 0.76 | PTPN11 (0.47) | ALOX15KDM4EALDH1A1NPC1MAPT | |
| SCHEMBL15920425 | 0.75 | GAA (0.62) | ALOX15KDM4EALDH1A1NPC1MAPT | |
| SCHEMBL27646939 | 0.75 | GUSB (0.49) | ALOX15KDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL27620753 | 0.73 | GUSB (0.51) | KDM4EALDH1A1HSD17B10HPGDHDAC1 | |
| SCHEMBL27639574 | 0.73 | GUSB (0.48) | ALOX15KDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL21439882 | 0.73 | TNF (0.68) | ALOX15KDM4EALDH1A1NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3036226-B1 | INHIBITORS OF HUMAN 12/15-LIPOXYGENASE | MASSACHUSETTS GEN HOSPITAL (US) | 2020-01-08 | — | — | EP | disclosed |
| EP-3036226-B1 | INHIBITORS OF HUMAN 12/15-LIPOXYGENASE | MASSACHUSETTS GEN HOSPITAL (US) | 2020-01-08 | — | — | EP | disclosed |
| US-10287279-B2 | Inhibitors of human 12/15-lipoxygenase | THE CHILDREN'S HOSPITAL CORPORATION (US) | 2019-05-14 | — | — | US | disclosed |
| US-10287279-B2 | Inhibitors of human 12/15-lipoxygenase | THE CHILDREN'S HOSPITAL CORPORATION (US) | 2019-05-14 | — | — | US | disclosed |
| US-20160168137-A1 | INHIBITORS OF HUMAN 12/15-LIPOXYGENASE | THE GENERAL HOSPITAL CORPORATION (US) | 2016-06-16 | — | — | US | disclosed |
| US-20160168137-A1 | INHIBITORS OF HUMAN 12/15-LIPOXYGENASE | THE GENERAL HOSPITAL CORPORATION (US) | 2016-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10287279-B2 | Inhibitors of human 12/15-lipoxygenase | ALOX15, ALOX12, ALOX15B | ALOX15 1/4885KDM4E 3629/4885ALDH1A1 3013/4885 |
| US-20160168137-A1 | INHIBITORS OF HUMAN 12/15-LIPOXYGENASE | ALOX15, ALOX12, ALOX15B | ALOX15 1/4885KDM4E 3629/4885ALDH1A1 3013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.