SCHEMBL15317547

SCHEMBL15317547

CCCCCCCCCc1cc(F)c(C(F)(F)Oc2cnc(C(F)(F)Oc3ccc(OC(F)(F)F)cc3)nc2)c(F)c1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG P37231 2/20 0.34
ALOX5 P09917 1/20 0.34
MAPT P10636 1/20 0.33
RAB9A P51151 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
FAAH O00519 1/20 0.33
CASP3 P42574 1/20 0.33
SENP8 Q96LD8 1/20 0.33
SENP7 Q9BQF6 1/20 0.33
SENP6 Q9GZR1 1/20 0.33
FUT7 Q11130 1/20 0.33
SCN9A Q15858 1/20 0.33
RXRA P19793 1/20 0.32
GRIN1 Q05586 1/20 0.32
GRIN2B Q13224 1/20 0.32
HDAC3 O15379 1/20 0.32
HDAC1 Q13547 1/20 0.32
HDAC2 Q92769 1/20 0.32
PRMT6 Q96LA8 1/20 0.32
PPARA Q07869 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15317541 0.87 FUT7 (0.32) MAPTRAB9AL3MBTL1CASP3SENP8
SCHEMBL7729318 0.80 FAAH (0.39) PPARGFAAHPPARAMEN1USP2
SCHEMBL7729601 0.80 THRB (0.38) PPARGALOX5FAAHPPARAMEN1
SCHEMBL15317550 0.80 MAPT (0.33) MAPTRAB9AL3MBTL1CASP3SENP8
SCHEMBL7735344 0.79 HTR2A (0.41) PPARGFAAHPPARAMEN1USP2
SCHEMBL7732860 0.79 HTR2A (0.41) PPARGFAAHPPARAMEN1USP2
SCHEMBL7729582 0.79 HTR2A (0.41) PPARGFAAHPPARAMEN1USP2
SCHEMBL15317545 0.79 MAPT (0.34) PPARGMAPTRAB9AL3MBTL1CASP3
SCHEMBL15317553 0.78 RARB (0.34) PPARGMAPTRAB9AL3MBTL1FAAH
SCHEMBL7729381 0.78 HTR2A (0.40) PPARGFAAHPPARAMEN1USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9133397-B2 Tricyclic compound having a plurality of CF2O bonding groups, liquid crystal composition, and liquid crystal display device JNC CORPORATION (JP) 2015-09-15 US disclosed
US-9133397-B2 Tricyclic compound having a plurality of CF2O bonding groups, liquid crystal composition, and liquid crystal display device JNC CORPORATION (JP) 2015-09-15 US disclosed
US-20130271719-A1 TRICYCLIC COMPOUND HAVING A PLURALITY OF CF2O BONDING GROUPS, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY DEVICE JNC PETROCHEMICAL CORPORATION (JP) 2013-10-17 US disclosed
US-20130271719-A1 TRICYCLIC COMPOUND HAVING A PLURALITY OF CF2O BONDING GROUPS, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY DEVICE JNC PETROCHEMICAL CORPORATION (JP) 2013-10-17 US disclosed