SCHEMBL15317545

SCHEMBL15317545

CCCCCCc1cc(F)c(C(F)(F)Oc2ccc(C(F)(F)Oc3ccc(F)c(F)c3)nc2)c(F)c1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.34
RAB9A P51151 2/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
CASP3 P42574 1/20 0.34
SENP8 Q96LD8 1/20 0.34
SENP7 Q9BQF6 1/20 0.34
SENP6 Q9GZR1 1/20 0.34
FUT7 Q11130 1/20 0.34
MOGAT2 Q3SYC2 5/20 0.33
PPARG P37231 2/20 0.33
PPARA Q07869 2/20 0.33
APLNR P35414 1/20 0.32
SMN1; SMN2 Q16637 2/20 0.31
NPC1 O15118 1/20 0.31
STAT3 P40763 1/20 0.31
ATM Q13315 1/20 0.31
MEN1 O00255 1/20 0.31
USP2 O75604 1/20 0.31
ALDH1A1 P00352 1/20 0.31
LMNA P02545 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15317542 0.87 MAPT (0.33) MAPTRAB9AL3MBTL1CASP3SENP8
SCHEMBL15317559 0.82 RAB9A (0.40) MAPTRAB9AL3MBTL1CASP3SENP8
SCHEMBL14226686 0.81 RAB9A (0.42) MAPTRAB9AL3MBTL1CASP3SENP8
SCHEMBL15317547 0.79 PPARG (0.34) MAPTRAB9AL3MBTL1CASP3SENP8
SCHEMBL15317563 0.78 RAB9A (0.43) MAPTRAB9AL3MBTL1CASP3SENP8
SCHEMBL16377239 0.78 RARB (0.45) MAPTRAB9AL3MBTL1CASP3SENP8
SCHEMBL12357428 0.77 RAB9A (0.49) MAPTRAB9AL3MBTL1CASP3SENP8
SCHEMBL15317541 0.76 FUT7 (0.32) MAPTRAB9AL3MBTL1CASP3SENP8
SCHEMBL15317554 0.76 MAPT (0.36) MAPTRAB9AL3MBTL1CASP3SENP8
SCHEMBL12357234 0.76 ALOX5AP (0.39) MAPTRAB9AL3MBTL1CASP3SENP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9133397-B2 Tricyclic compound having a plurality of CF2O bonding groups, liquid crystal composition, and liquid crystal display device JNC CORPORATION (JP) 2015-09-15 US disclosed
US-20130271719-A1 TRICYCLIC COMPOUND HAVING A PLURALITY OF CF2O BONDING GROUPS, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY DEVICE JNC PETROCHEMICAL CORPORATION (JP) 2013-10-17 US disclosed