Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.31 |
| ▸ | C1S | P09871 | 2/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.31 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.31 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.30 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15107329 | 0.90 | PDE4D (0.35) | MAPK14PDE4D | |
| SCHEMBL12892440 | 0.88 | PIK3CD (0.42) | MAPK14ADORA2APIK3CDADORA3PDE4D | |
| SCHEMBL12879883 | 0.88 | PIK3CD (0.42) | MAPK14ADORA2APIK3CDADORA3PDE4D | |
| SCHEMBL9268585 | 0.85 | CSNK1D (0.38) | EHMT2CSNK1D | |
| SCHEMBL8065929 | 0.84 | CSNK1D (0.34) | ADORA2APIK3CDADORA3PDE4DADORA1 | |
| SCHEMBL8055904 | 0.80 | MLYCD (0.35) | PDE4DEHMT2CSNK1D | |
| SCHEMBL16503338 | 0.80 | MAPK1 (0.32) | MAPK1PDE4DEHMT2 | |
| SCHEMBL12879583 | 0.80 | ALDH1A1 (0.33) | ADORA2AMAPK1PIK3CDADORA3PDE4D | |
| SCHEMBL15315383 | 0.80 | ALDH1A1 (0.33) | ADORA2AMAPK1PIK3CDADORA3PDE4D | |
| SCHEMBL15317965 | 0.79 | ADAMTS5 (0.31) | C1S |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9090626-B2 | Piperazino-dihydrothienopyrimidine derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-07-28 | — | — | US | disclosed |
| US-20130274264-A1 | PIPERAZINO-DIHYDROTHIENOPYRIMIDINE DERIVATIVES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130274264-A1 | PIPERAZINO-DIHYDROTHIENOPYRIMIDINE DERIVATIVES | PDE4A, PDE12, PDE4B | MAPK14 2787/4885ADORA2A 1909/4885MAPK1 2836/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.