Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15320385 | 0.80 | ABHD6 (0.31) | — | |
| SCHEMBL15321041 | 0.78 | MAOA (0.33) | HTTMAOA | |
| SCHEMBL19230550 | 0.75 | HTT (0.44) | HTTALDH1A1CYP2D6HPGDTSHR | |
| SCHEMBL14077115 | 0.75 | HTT (0.44) | HTTALDH1A1CYP2D6HPGDTSHR | |
| SCHEMBL21777429 | 0.74 | TNKS (0.40) | HTTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL32686723 | 0.73 | CYP19A1 (0.37) | DRD1KDM4EALDH1A1DRD2 | |
| SCHEMBL21777353 | 0.72 | ABHD6 (0.32) | — | |
| SCHEMBL15319670 | 0.70 | DRD1 (0.49) | MAOADRD1KDM4EALDH1A1 | |
| SCHEMBL21777282 | 0.70 | — | — | |
| SCHEMBL20241845 | 0.69 | CYP2A13 (0.36) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2834233-A1 | NEW ALPHA2 ADRENOCEPTOR AGONISTS | Orion Corporation (FI) | 2015-02-11 | — | — | EP | disclosed |
| WO-2013150173-A1 | NEW ALPHA2 ADRENOCEPTOR AGONISTS | ORION CORPORATION (FI) | 2013-10-10 | — | — | WO | disclosed |