Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 10/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 4/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.32 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16534972 | 0.79 | DRD1 (0.39) | DRD1KDM4EALDH1A1HTR2CADRA2A | |
| SCHEMBL15319889 | 0.78 | DRD1 (0.46) | DRD1KDM4EALDH1A1HTR2CHTR2B | |
| SCHEMBL15319953 | 0.74 | TSHR (0.37) | DRD1KDM4EALDH1A1MAOA | |
| SCHEMBL15319521 | 0.73 | DRD1 (0.42) | DRD1KDM4EALDH1A1HTR2CKDM1A | |
| SCHEMBL15319765 | 0.73 | ADRA2A (0.45) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL15319294 | 0.71 | DRD1 (0.39) | DRD1HTR2CMAOAHTR2BHTR2A | |
| SCHEMBL15319634 | 0.70 | HTT (0.35) | DRD1KDM4EALDH1A1MAOA | |
| SCHEMBL7919137 | 0.67 | KDM4E (0.40) | KDM4EALDH1A1HTR2CADRA2AADRA2B | |
| SCHEMBL21079230 | 0.67 | KDM4E (0.40) | KDM4EALDH1A1HTR2CADRA2AADRA2B | |
| SCHEMBL15319240 | 0.67 | KDM4E (0.37) | KDM4EALDH1A1HTR2CMAOAKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2834233-A1 | NEW ALPHA2 ADRENOCEPTOR AGONISTS | Orion Corporation (FI) | 2015-02-11 | — | — | EP | disclosed |
| WO-2013150173-A1 | NEW ALPHA2 ADRENOCEPTOR AGONISTS | ORION CORPORATION (FI) | 2013-10-10 | — | — | WO | disclosed |