Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 4/20 | 0.46 |
| ▸ | ACHE | P22303 | 3/20 | 0.46 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
| ▸ | CCNC | P24863 | 3/20 | 0.33 |
| ▸ | CDK8 | P49336 | 3/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12402438 | 0.82 | ALOX5 (0.45) | GSTP1ALOX5KDM4ENOTUMERO1A | |
| SCHEMBL3646655 | 0.76 | GSTP1 (0.52) | GSTP1HDAC4HDAC2HDAC8ALOX5 | |
| SCHEMBL15323008 | 0.73 | PTPN1 (0.43) | BACE1HDAC4HDAC2HDAC8ALOX5 | |
| SCHEMBL31406988 | 0.70 | GSTP1 (0.57) | BACE1ACHEGSTP1HDAC4HDAC2 | |
| SCHEMBL31406989 | 0.70 | GSTP1 (0.57) | BACE1ACHEGSTP1HDAC4HDAC2 | |
| SCHEMBL868484 | 0.70 | GSTP1 (0.57) | BACE1ACHEGSTP1HDAC4HDAC2 | |
| SCHEMBL2166049 | 0.68 | NPC1 (0.42) | HDAC4HDAC2HDAC8KDM4ECYP1A2 | |
| SCHEMBL2166046 | 0.68 | NPC1 (0.42) | HDAC4HDAC2HDAC8KDM4ECYP1A2 | |
| SCHEMBL2166053 | 0.68 | NPC1 (0.42) | HDAC4HDAC2HDAC8KDM4ECYP1A2 | |
| SCHEMBL7945130 | 0.67 | GSTP1 (0.52) | BACE1ACHEGSTP1HDAC4HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8563548-B2 | Methylene furanone derivatives and use of said derivatives as a photoprotecting or antioxidant or depigmentation agent in cosmetic or dermatological compositions | PIERRE FABRE DERMO-COSMETIQUE (FR) | 2013-10-22 | — | — | US | disclosed |