Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.39 |
| ▸ | ITK | Q08881 | 3/20 | 0.39 |
| ▸ | BCL6 | P41182 | 2/20 | 0.39 |
| ▸ | BTK | Q06187 | 4/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.37 |
| ▸ | ULK1 | O75385 | 1/20 | 0.36 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15323804 | 0.89 | EGFR (0.44) | EGFRITKBCL6BTKALK | |
| SCHEMBL15323103 | 0.86 | EGFR (0.39) | EGFRITKBCL6BTKALK | |
| SCHEMBL15321742 | 0.86 | EGFR (0.39) | EGFRITKBCL6BTKALK | |
| SCHEMBL15322328 | 0.78 | EGFR (0.40) | EGFRITKBCL6BTKALK | |
| SCHEMBL15320905 | 0.78 | EGFR (0.40) | EGFRITKBCL6BTKALK | |
| SCHEMBL19527724 | 0.76 | EGFR (0.40) | EGFRITKBCL6BTKALK | |
| SCHEMBL15320781 | 0.76 | BCL6 (0.46) | EGFRITKBCL6BTKALK | |
| SCHEMBL15321035 | 0.75 | BCL6 (0.48) | EGFRITKBCL6BTK | |
| SCHEMBL15337337 | 0.75 | BCL6 (0.48) | EGFRITKBCL6BTK | |
| SCHEMBL19527748 | 0.74 | TBK1 (0.37) | EGFRITKALKULK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2833889-A1 | PROTEIN KINASE C INHIBITORS AND USES THEREOF | Rigel Pharmaceuticals, Inc. (US) | 2015-02-11 | — | — | EP | disclosed |
| WO-2013152198-A1 | PROTEIN KINASE C INHIBITORS AND USES THEREOF | RIGEL PHARMACEUTICALS, INC. (US) | 2013-10-10 | — | — | WO | disclosed |