Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 6/20 | 0.36 |
| ▸ | EGFR | P00533 | 5/20 | 0.36 |
| ▸ | ITK | Q08881 | 4/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | ULK1 | O75385 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18995012 | 0.86 | BCL6 (0.43) | SYKEGFRITKSCN9A | |
| SCHEMBL19527725 | 0.86 | TNIK (0.39) | TBK1SYKEGFRITKFLT3 | |
| SCHEMBL18995069 | 0.84 | ULK1 (0.44) | SYKFLT3ULK1 | |
| SCHEMBL18995121 | 0.83 | NPC1 (0.47) | TBK1NPC1RAB9AGRM5 | |
| SCHEMBL19527683 | 0.81 | SYK (0.47) | SYKEGFRITKNPC1RAB9A | |
| SCHEMBL15323103 | 0.74 | EGFR (0.39) | EGFRITKALKULK1 | |
| SCHEMBL15321742 | 0.74 | EGFR (0.39) | EGFRITKALKULK1 | |
| SCHEMBL15323107 | 0.74 | EGFR (0.39) | EGFRITKALKULK1 | |
| SCHEMBL19836644 | 0.73 | NPC1 (0.49) | TBK1SYKEGFRNPC1RAB9A | |
| SCHEMBL19527697 | 0.73 | SYK (0.48) | SYKTNIKNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2833889-B1 | PROTEIN KINASE C INHIBITORS AND USES THEREOF | RIGEL PHARMACEUTICALS INC (US) | 2017-11-01 | — | — | EP | disclosed |