Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 9/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.49 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7449832 | 0.81 | MEN1 (0.54) | MEN1KMT2AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL15322299 | 0.77 | KMT2A (0.41) | MEN1KMT2AMAPTLMNASMN1; SMN2 | |
| SCHEMBL10277259 | 0.74 | KMT2A (0.62) | MEN1KMT2AMAPTLMNASMN1; SMN2 | |
| SCHEMBL31210860 | 0.69 | LMNA (0.46) | MEN1KMT2AMAPTLMNASMN1; SMN2 | |
| SCHEMBL12877828 | 0.69 | LMNA (0.46) | MEN1KMT2AMAPTLMNASMN1; SMN2 | |
| SCHEMBL10277357 | 0.69 | PDE10A (0.51) | MEN1KMT2AMAPTLMNASMN1; SMN2 | |
| SCHEMBL16244483 | 0.68 | MAPT (0.42) | MEN1KMT2AMAPTLMNASMN1; SMN2 | |
| SCHEMBL18307345 | 0.68 | ALDH1A1 (0.42) | MEN1KMT2AMAPTLMNASMN1; SMN2 | |
| SCHEMBL30424951 | 0.68 | MAPT (0.42) | MEN1KMT2AMAPTLMNASMN1; SMN2 | |
| SCHEMBL30046587 | 0.68 | MAPT (0.39) | MEN1KMT2AMAPTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013153535-A1 | TRICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-10-17 | — | — | WO | disclosed |
| WO-2013153535-A1 | TRICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-10-17 | — | — | WO | disclosed |