Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.36 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.36 |
| ▸ | NPY1R | P25929 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15323178 | 0.77 | MEN1 (0.49) | KMT2AMEN1SMN1; SMN2TDP1ALDH1A1 | |
| SCHEMBL27711986 | 0.72 | CYP1A2 (0.46) | KMT2AMEN1TDP1ALDH1A1CYP1A2 | |
| SCHEMBL31182415 | 0.71 | MEN1 (0.46) | KMT2AMEN1SMN1; SMN2TDP1ALDH1A1 | |
| SCHEMBL31500715 | 0.71 | GPR35 (0.34) | KMT2AMEN1TDP1ALDH1A1CYP1A2 | |
| SCHEMBL25637697 | 0.70 | MEN1 (0.63) | KMT2AMEN1TDP1ALDH1A1CYP1A2 | |
| SCHEMBL29363774 | 0.68 | GRIN2D (0.51) | KMT2AMEN1SMN1; SMN2TDP1ALDH1A1 | |
| SCHEMBL28977893 | 0.68 | GRIN2D (0.47) | KMT2AMEN1SMN1; SMN2TDP1ALDH1A1 | |
| SCHEMBL22805139 | 0.68 | GRIN2D (0.51) | KMT2AMEN1SMN1; SMN2TDP1ALDH1A1 | |
| SCHEMBL3502541 | 0.68 | MEN1 (0.50) | KMT2AMEN1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL5708856 | 0.68 | ALDH1A1 (0.36) | KMT2AMEN1TDP1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013153535-A1 | TRICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-10-17 | — | — | WO | disclosed |
| WO-2013153535-A1 | TRICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-10-17 | — | — | WO | disclosed |