Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.45 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.45 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.38 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.37 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.37 |
| ▸ | KDM4A | O75164 | 2/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.37 |
| ▸ | TET3 | O43151 | 1/20 | 0.37 |
| ▸ | OR51E2 | Q9H255 | 2/20 | 0.36 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.36 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | KDM6B | O15054 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL15323882 | 0.93 | EGLN1 (0.39) | LMNAEGLN1ALKBH5SUCNR1ALDH1A1 | |
| Succinic Acid SCHEMBL6854426 | 0.89 | LMNA (0.56) | LMNAEGLN1ALKBH5SUCNR1ALDH1A1 | |
| Succinic Acid SCHEMBL321511 | 0.89 | LMNA (0.56) | LMNAEGLN1ALKBH5SUCNR1ALDH1A1 | |
| Succinic Acid SCHEMBL19478236 | 0.89 | LMNA (0.56) | LMNAEGLN1ALKBH5SUCNR1ALDH1A1 | |
| Succinic Acid SCHEMBL15323337 | 0.89 | EGLN1 (0.36) | LMNAEGLN1ALKBH5SUCNR1ALDH1A1 | |
| Succinic Acid SCHEMBL29758477 | 0.89 | LMNA (0.56) | LMNAEGLN1ALKBH5SUCNR1ALDH1A1 | |
| Succinic Acid SCHEMBL7186939 | 0.87 | LMNA (0.53) | LMNAEGLN1ALKBH5SUCNR1ALDH1A1 | |
| Malonic Acid SCHEMBL15323828 | 0.85 | LMNA (0.45) | LMNAALDH1A1AKR1B1SLC22A6OR51E2 | |
| Glycerin SCHEMBL1109930 | 0.84 | — | — | |
| Glycerin SCHEMBL31469212 | 0.84 | LMNA (0.64) | LMNAALDH1A1AKR1B1OR51E2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2836833-A1 | PRENATAL SCREENING FOR DOWN SYNDROME AND TRISOMY 18 | Wayne State University (US) | 2015-02-18 | — | — | EP | disclosed |
| WO-2013155456-A1 | PRENATAL SCREENING FOR DOWN SYNDROME AND TRISOMY 18 | WAYNE STATE UNIVERSITY (US) | 2013-10-17 | — | — | WO | disclosed |