Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.53 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.53 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.53 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.43 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.42 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.42 |
| ▸ | KDM4A | O75164 | 2/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.42 |
| ▸ | TET3 | O43151 | 1/20 | 0.42 |
| ▸ | OR51E2 | Q9H255 | 2/20 | 0.41 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.41 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL6854426 | 0.97 | LMNA (0.56) | LMNAEGLN1ALKBH5SUCNR1ALDH1A1 | |
| Succinic Acid SCHEMBL29758477 | 0.97 | LMNA (0.56) | LMNAEGLN1ALKBH5SUCNR1ALDH1A1 | |
| Succinic Acid SCHEMBL321511 | 0.97 | LMNA (0.56) | LMNAEGLN1ALKBH5SUCNR1ALDH1A1 | |
| Succinic Acid SCHEMBL19478236 | 0.97 | LMNA (0.56) | LMNAEGLN1ALKBH5SUCNR1ALDH1A1 | |
| Glutarate SCHEMBL7174566 | 0.89 | SLC22A6 (0.58) | LMNAEGLN1ALKBH5SUCNR1ALDH1A1 | |
| Glycerin SCHEMBL30929982 | 0.87 | LMNA (0.69) | LMNAALDH1A1SLC22A6OR51E2TSHR | |
| Glycerin SCHEMBL44491 | 0.87 | LMNA (0.69) | LMNAALDH1A1SLC22A6OR51E2TSHR | |
| Glycerin SCHEMBL7030045 | 0.87 | LMNA (0.69) | LMNAALDH1A1SLC22A6OR51E2TSHR | |
| Glycerin SCHEMBL28563108 | 0.87 | LMNA (0.69) | LMNAALDH1A1SLC22A6OR51E2TSHR | |
| Glycerin SCHEMBL4671978 | 0.87 | LMNA (0.69) | LMNAALDH1A1SLC22A6OR51E2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1129120-B1 | MODIFIED POLYISOCYANATES | RHODIA CHIMIE SA (FR) | 2003-12-10 | — | — | EP | claimed |