Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | HTR4 | Q13639 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 5/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | DRD5 | P21918 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15324655 | 0.85 | KDM4E (0.50) | KDM4EALDH1A1HTR4GAAHSD17B10 | |
| SCHEMBL7398883 | 0.83 | KDM4E (0.58) | KDM4EALDH1A1HTR4GAAHSD17B10 | |
| SCHEMBL13603003 | 0.81 | KDM4E (0.55) | KDM4EALDH1A1HTR4GAAHSD17B10 | |
| SCHEMBL15322464 | 0.79 | PDGFRB (0.43) | KDM4EALDH1A1HTR4MAPTHPGD | |
| SCHEMBL29054678 | 0.76 | KDM4E (0.53) | KDM4EALDH1A1HTR4GAAHSD17B10 | |
| SCHEMBL30507871 | 0.76 | KDM4E (0.53) | KDM4EALDH1A1HTR4GAAHSD17B10 | |
| SCHEMBL7402316 | 0.75 | ALDH1A1 (0.55) | KDM4EALDH1A1HTR4GAAHSD17B10 | |
| SCHEMBL14810489 | 0.75 | HTR4 (0.58) | KDM4EALDH1A1HTR4GAACHRM2 | |
| SCHEMBL2698798 | 0.74 | KDM4E (0.40) | KDM4EALDH1A1GAAHSD17B10MAPT | |
| SCHEMBL6848305 | 0.73 | KDM4E (0.56) | KDM4EALDH1A1GAAHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013153535-A1 | TRICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-10-17 | — | — | WO | disclosed |
| WO-2013153535-A1 | TRICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-10-17 | — | — | WO | disclosed |