Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | HTR4 | Q13639 | 11/20 | 0.36 |
| ▸ | HTR2C | P28335 | 3/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.36 |
| ▸ | HTR1D | P28221 | 2/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15323760 | 0.85 | KDM4E (0.54) | KDM4EALDH1A1HSD17B10GAAMAPT | |
| SCHEMBL15324928 | 0.81 | PDGFRB (0.43) | KDM4EALDH1A1GAAMAPTHPGD | |
| SCHEMBL7398883 | 0.80 | KDM4E (0.58) | KDM4EALDH1A1HSD17B10GAAMAPT | |
| SCHEMBL13603003 | 0.77 | KDM4E (0.55) | KDM4EALDH1A1HSD17B10GAAMAPT | |
| SCHEMBL29054678 | 0.73 | KDM4E (0.53) | KDM4EALDH1A1HSD17B10GAAMAPT | |
| SCHEMBL30507871 | 0.73 | KDM4E (0.53) | KDM4EALDH1A1HSD17B10GAAMAPT | |
| SCHEMBL7402316 | 0.72 | ALDH1A1 (0.55) | KDM4EALDH1A1HSD17B10GAAMAPT | |
| SCHEMBL14810489 | 0.71 | HTR4 (0.58) | KDM4EALDH1A1GAAABL1HTR4 | |
| SCHEMBL6848305 | 0.70 | KDM4E (0.56) | KDM4EALDH1A1HSD17B10GAAMAPT | |
| SCHEMBL7398875 | 0.70 | HTR4 (0.55) | KDM4EALDH1A1GAAMAPTHTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2833920-A2 | MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF BIOLOGICS AND PROTEINS ASSOCIATED WITH HUMAN DISEASE | Moderna Therapeutics, Inc. (US) | 2015-02-11 | — | — | EP | disclosed |
| WO-2013153535-A1 | TRICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-10-17 | — | — | WO | disclosed |
| WO-2013153535-A1 | TRICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-10-17 | — | — | WO | disclosed |
| WO-2013151666-A2 | MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF BIOLOGICS AND PROTEINS ASSOCIATED WITH HUMAN DISEASE | modeRNA Therapeutics (US) | 2013-10-10 | — | — | WO | disclosed |