Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.42 |
| ▸ | CCNC | P24863 | 2/20 | 0.41 |
| ▸ | CDK8 | P49336 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | DGKZ | Q13574 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22425610 | 1.00 | TLR7 (0.43) | TLR7PDE1BJAK2JAK1PDE10A | |
| SCHEMBL1929059 | 0.84 | JAK2 (0.43) | TLR7PDE1BJAK2JAK1PDE10A | |
| SCHEMBL9953012 | 0.84 | TLR7 (0.45) | TLR7PDE1BJAK2JAK1PDE10A | |
| SCHEMBL15312373 | 0.84 | TLR7 (0.45) | TLR7PDE1BJAK2JAK1PDE10A | |
| SCHEMBL15317724 | 0.84 | TLR7 (0.41) | TLR7PDE1BJAK2JAK1PDE10A | |
| SCHEMBL14857043 | 0.81 | DGKZ (0.41) | TLR7PDE1BJAK2JAK1CCNC | |
| SCHEMBL9953021 | 0.79 | KCNJ1 (0.45) | PDE1BJAK2JAK1ALDH1A1LMNA | |
| SCHEMBL25153282 | 0.78 | LPL (0.43) | TLR7PDE1BJAK2JAK1PDE10A | |
| SCHEMBL15312545 | 0.77 | CYP51A1 (0.40) | TLR7PDE1BJAK2JAK1PDE10A | |
| SCHEMBL13162684 | 0.76 | CCNC (0.41) | TLR7PDE1BJAK2JAK1PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9073892-B2 | Indazolyl triazol derivatives | MERCK SERONO S.A. (CH) | 2015-07-07 | — | — | US | disclosed |
| US-20130274241-A1 | INDAZOLYL TRIAZOL DERIVATIVES | MERCK SERONO S.A. - INTELLECTUAL PROPERTY (CH) | 2013-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130274241-A1 | INDAZOLYL TRIAZOL DERIVATIVES | NFATC1, IL5, CD4 | TLR7 156/4885PDE1B 4085/4885JAK2 66/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.