Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 4/20 | 0.40 |
| ▸ | CLK3 | P49761 | 4/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | WNT1 | P04628 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12515439 | 0.82 | HPGDS (0.46) | HPGDMEN1KMT2ARAB9AGAA | |
| SCHEMBL12011608 | 0.81 | HDAC4 (0.48) | HPGDMEN1KMT2ARAB9AGAA | |
| SCHEMBL18474684 | 0.79 | TP53 (0.49) | HPGDMEN1KMT2ARAB9AMAPT | |
| SCHEMBL22648436 | 0.79 | KMT2A (0.46) | HPGDMEN1KMT2ARAB9AGAA | |
| SCHEMBL22648403 | 0.78 | RAB9A (0.51) | HPGDMEN1KMT2ARAB9AGAA | |
| SCHEMBL18475187 | 0.78 | PARP1 (0.43) | MAPTAAK1L3MBTL1 | |
| SCHEMBL1947815 | 0.75 | HPGD (0.62) | HPGDMEN1KMT2ARAB9AGAA | |
| SCHEMBL12313962 | 0.75 | NAMPT (0.48) | CA1 | |
| SCHEMBL19169876 | 0.73 | HDAC3 (0.60) | HPGDMEN1KMT2ARAB9AGAA | |
| SCHEMBL23518443 | 0.72 | RAB9A (0.76) | HPGDMEN1KMT2ARAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013151708-A1 | INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF | SAMUMED, LLC (US) | 2013-10-10 | — | — | WO | disclosed |