Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MGAM | O43451 | 1/20 | 0.44 |
| ▸ | SI | P14410 | 1/20 | 0.44 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CETP | P11597 | 1/20 | 0.34 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16190580 | 1.00 | GAA (0.44) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL195939 | 1.00 | GAA (0.44) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL19466094 | 0.86 | GAA (0.43) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL17275158 | 0.86 | ALDH1A1 (0.45) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL15286426 | 0.86 | GAA (0.43) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL18120819 | 0.86 | GAA (0.43) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL899414 | 0.84 | GAA (0.41) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL9362556 | 0.84 | NAAA (0.34) | ALDH1A1TSHRTDP1CHRM1LMNA | |
| SCHEMBL6328626 | 0.83 | ALDH1A1 (0.46) | ALDH1A1TSHRHSD17B10 | |
| SCHEMBL6322471 | 0.83 | ALDH1A1 (0.46) | ALDH1A1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0736606-B1 | Process for the enzymatic preparation of intermediates for the synthesis of befloxatone | SANOFI SYNTHELABO (FR) | 2002-01-02 | — | — | EP | claimed |
| US-5716841-A | Process for the resolution of ethyl 4,4,4-trifluoro-3(R)-hydroxybutanoate using lipase from candida | SYNTHELABO (FR) | 1998-02-10 | — | — | US | claimed |
| JP-8289799-A | — | — | None | — | — | JP | disclosed |
| CN-118307409-A | Asymmetric synthesis method of beta-hydroxy acid ester with optical purity | 河北悦民生化有限公司 | 2024-07-09 | — | — | CN | disclosed |
| CN-104630242-B | A kind of carbonyl reduction enzyme gene, codase, carrier, engineering bacteria and its application | 浙江工业大学 | 2017-12-05 | — | — | CN | disclosed |
| CN-104630242-A | Carbonyl reductase gene, codase, vector, engineering bacterium and application thereof | UNIV ZHEJIANG TECHNOLOGY | 2015-05-20 | — | — | CN | disclosed |
| US-20130196987-A1 | MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS | EISAI CO., LTD. (JP) | 2013-08-01 | — | — | US | disclosed |
| US-8329742-B2 | Macrocyclic compounds useful as pharmaceuticals | EISAI CO., LTD. (JP) | 2012-12-11 | — | — | US | disclosed |
| US-20110144101-A1 | MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS | EISAI CO., LTD. (JP) | 2011-06-16 | — | — | US | disclosed |
| US-20110144101-A1 | MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS | EISAI CO., LTD. (JP) | 2011-06-16 | — | — | US | disclosed |
| EP-2308861-A1 | Macrocyclic compounds useful as pharmaceuticals | Eisai R&D Management Co., Ltd. (JP) | 2011-04-13 | — | — | EP | disclosed |
| US-5716841-A | Process for the resolution of ethyl 4,4,4-trifluoro-3(R)-hydroxybutanoate using lipase from candida | SYNTHELABO (FR) | 1998-02-10 | — | — | US | disclosed |
| EP-0617109-B1 | Liquid crystal material, liquid crystal composition and liquid crystal element | MITSUI PETROCHEMICAL IND (JP) | 1997-09-17 | — | — | EP | disclosed |
| JP-H08289799-A | ENZYMATIC PRODUCTION OF INTERMEDIATE IN SYNTHESIZING BEFLOXATONE | SYNTHELABO SA | 1996-11-05 | — | — | JP | disclosed |
| US-5422039-A | Having a chiral center-containing a tetralinylene ring as well as a second chiral center; cells having high temperature operating range; high switching speed, low voltage and stable contrast | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1995-06-06 | — | — | US | disclosed |
| US-5356561-A | Carboxylate compounds, liquid crystal compositions and liquid crystal elements containing said compounds and method of optical modulation using said elements | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1994-10-18 | — | — | US | disclosed |
| EP-0617109-A1 | Liquid crystal material, liquid crystal composition and liquid crystal element | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1994-09-28 | — | — | EP | disclosed |
| EP-0484849-B1 | Optically active alcohol, process for producing same and liquid crystal compound using same | MITSUBISHI GAS CHEMICAL CO (JP) | 1994-08-31 | — | — | EP | disclosed |
| US-5264150-A | Fluorinated, ether aromatic ester compounds | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 1993-11-23 | — | — | US | disclosed |
| EP-0484849-A1 | Optically active alcohol, process for producing same and liquid crystal compound using same | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 1992-05-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144101-A1 | MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS | FLT1, TBXA2R, VEGFA | GAA 1289/4885MGAM 4244/4885SI 4591/4885 |
| US-20130196987-A1 | MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS | FLT4, VEGFA, FLT1 | GAA 799/4885MGAM 3001/4885SI 3376/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.