Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL1759319 | 0.87 | MEN1 (0.71) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL8497866 | 0.84 | MEN1 (0.67) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL29175316 | 0.84 | MEN1 (0.67) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL19988134 | 0.82 | MEN1 (0.56) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL3433733 | 0.81 | MEN1 (0.62) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL5655709 | 0.81 | MEN1 (0.62) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL9443897 | 0.81 | MEN1 (0.62) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL8772229 | 0.81 | MEN1 (0.62) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL1278460 | 0.81 | MEN1 (0.62) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL7193959 | 0.79 | MEN1 (0.83) | MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12400840-B2 | Substrate processing apparatus, substrate holder, and method of manufacturing semiconductor device | Kokusai Electric Corporation (JP) | 2025-08-26 | — | — | US | disclosed |
| US-20230187188-A1 | SUBSTRATE PROCESSING APPARATUS, SUBSTRATE HOLDER, AND METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE | Kokusai Electric Corporation (JP) | 2023-06-15 | — | — | US | disclosed |
| US-11359285-B2 | Substrate processing apparatus, heater and method of manufacturing semiconductor device | Kokusai Electric Corporation (JP) | 2022-06-14 | — | — | US | disclosed |
| US-20200173024-A1 | Substrate Processing Apparatus, Heater and Method of Manufacturing Semiconductor Device | KOKUSAI ELECTRIC CORP (JP) | 2020-06-04 | — | — | US | disclosed |
| US-10597780-B2 | Substrate processing apparatus, heater and method of manufacturing semiconductor device | Kokusai Electric Corporation (JP) | 2020-03-24 | — | — | US | disclosed |
| US-9885114-B2 | Film forming apparatus | TOKYO ELECTRON LIMITED (JP) | 2018-02-06 | — | — | US | disclosed |
| US-20170335458-A1 | Substrate Processing Apparatus, Heater and Method of Manufacturing Semiconductor Device | Kokusai Electric Corporation (JP) | 2017-11-23 | — | — | US | disclosed |
| US-20150267298-A1 | FILM FORMING APPARATUS | TOKYO ELECTRON LIMITED (JP) | 2015-09-24 | — | — | US | disclosed |
| US-20110064958-A1 | WEATHER-RESISTANCE RESIN BASE MATERIAL AND OPTICAL ELEMENT | KONICA MINOLTA HOLDINGS, INC. (JP) | 2011-03-17 | — | — | US | disclosed |
| US-4789564-A | Hydridoaminosilane treatment for rendering surfaces water-repellent | UNION CARBIDE CORPORATION (US) | 1988-12-06 | — | — | US | disclosed |