Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL1759319 | 0.87 | MEN1 (0.71) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL29175316 | 0.84 | MEN1 (0.67) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL8497866 | 0.84 | MEN1 (0.67) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL1532733 | 0.81 | MEN1 (0.62) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL3433733 | 0.81 | MEN1 (0.62) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL9443897 | 0.81 | MEN1 (0.62) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL5655709 | 0.81 | MEN1 (0.62) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL1278460 | 0.81 | MEN1 (0.62) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL7193959 | 0.79 | MEN1 (0.83) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL28216031 | 0.79 | MEN1 (0.83) | MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997031880-A1 | PROCESS FOR PREPARATION OF AROMATIC AND HETEROAROMATIC MOLECULES | WARNER-LAMBERT COMPANY (US) | 1997-09-04 | — | — | WO | claimed |
| EP-0799245-A1 | BIODEGRADABLE THERMOPLASTIC STARCHES | BASF AKTIENGESELLSCHAFT (DE) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996020220-A1 | BIODEGRADABLE THERMOPLASTIC STARCHES | BASF AKTIENGESELLSCHAFT (DE) | 1996-07-04 | — | — | WO | disclosed |
| EP-0632811-A1 | PRODUCTION OF TRIFLUOROVINYL ETHERS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1995-01-11 | — | — | EP | disclosed |
| WO-1993020085-A1 | PRODUCTION OF TRIFLUOROVINYL ETHERS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1993-10-14 | — | — | WO | disclosed |