Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 20/20 | 0.66 |
| ▸ | CTSS | P25774 | 16/20 | 0.57 |
| ▸ | CTSK | P43235 | 3/20 | 0.54 |
| ▸ | CTSB | P07858 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15327444 | 0.95 | CTSL (0.64) | CTSLCTSSCTSKCTSB | |
| SCHEMBL15327421 | 0.94 | CTSL (0.65) | CTSLCTSSCTSKCTSB | |
| SCHEMBL15327574 | 0.92 | CTSL (0.79) | CTSLCTSSCTSKCTSB | |
| SCHEMBL15327468 | 0.91 | CTSL (0.59) | CTSLCTSSCTSKCTSB | |
| SCHEMBL15327496 | 0.89 | CTSL (0.57) | CTSLCTSSCTSKCTSB | |
| SCHEMBL15327305 | 0.89 | CTSL (0.58) | CTSLCTSS | |
| SCHEMBL15327193 | 0.89 | CTSL (0.57) | CTSLCTSSCTSK | |
| SCHEMBL15327189 | 0.89 | CTSL (0.68) | CTSLCTSSCTSKCTSB | |
| SCHEMBL15327575 | 0.89 | CTSS (0.54) | CTSLCTSSCTSKCTSB | |
| SCHEMBL15327461 | 0.88 | CTSL (0.58) | CTSLCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421826-B1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | HOFFMANN LA ROCHE (CH) | 2013-10-23 | — | — | EP | claimed |