SCHEMBL15329852

SCHEMBL15329852

CCOc1ccc(C=O)c(F)c1[Si](C)(C)C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.41
ALDH1A1 P00352 9/20 0.39
GAA P10253 2/20 0.39
KDM4E B2RXH2 3/20 0.36
ERN1 O75460 2/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
MAPT P10636 2/20 0.35
MEN1 O00255 1/20 0.35
APAF1 O14727 1/20 0.35
USP2 O75604 1/20 0.35
THRB P10828 1/20 0.35
CASP1 P29466 1/20 0.35
BRCA1 P38398 1/20 0.35
CASP7 P55210 1/20 0.35
KMT2A Q03164 1/20 0.35
HPGD P15428 2/20 0.34
ALOX12 P18054 1/20 0.34
NTSR1 P30989 1/20 0.34
CCR6 P51684 1/20 0.34
MCL1 Q07820 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2544586 0.83 LMNA (0.49) LMNAALDH1A1GAAKDM4EERN1
SCHEMBL15330024 0.79 CTSL (0.33) LMNAALDH1A1GAAKDM4EL3MBTL1
SCHEMBL5042606 0.79 LMNA (0.45) LMNAALDH1A1GAAKDM4EERN1
SCHEMBL10010397 0.78 LMNA (0.44) LMNAALDH1A1GAAKDM4EERN1
SCHEMBL18988051 0.78 LMNA (0.44) LMNAALDH1A1GAAKDM4EERN1
SCHEMBL15339931 0.77 KDM4E (0.42) ALDH1A1GAAKDM4EMAPTHPGD
SCHEMBL15339929 0.77 ALDH1A1 (0.32) LMNAALDH1A1KDM4EMAPTMEN1
SCHEMBL28794383 0.76 LMNA (0.45) LMNAALDH1A1GAAKDM4EERN1
SCHEMBL1813429 0.74 ALDH1A1 (0.45) LMNAALDH1A1GAAKDM4EERN1
SCHEMBL1579244 0.73 ALDH1A1 (0.48) LMNAALDH1A1GAAKDM4EERN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9102871-B2 Liquid crystal compound showing negative dielectric anisotropy, liquid crystal composition and liquid crystal display device JNC CORPORATION (JP) 2015-08-11 US disclosed
US-9102871-B2 Liquid crystal compound showing negative dielectric anisotropy, liquid crystal composition and liquid crystal display device JNC CORPORATION (JP) 2015-08-11 US disclosed
US-20130277610-A1 LIQUID CRYSTAL COMPOUND SHOWING NEGATIVE DIELECTRIC ANISOTROPY, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC PETROCHEMICAL CORPORATION (JP) 2013-10-24 US disclosed
US-20130277610-A1 LIQUID CRYSTAL COMPOUND SHOWING NEGATIVE DIELECTRIC ANISOTROPY, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC PETROCHEMICAL CORPORATION (JP) 2013-10-24 US disclosed