SCHEMBL15330280

SCHEMBL15330280

C=C(Br)COc1ccc(C=O)cc1OC

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FDPS P14324 1/20 0.65
ALDH1A1 P00352 11/20 0.64
SMN1; SMN2 Q16637 5/20 0.64
POLB P06746 2/20 0.60
TSHR P16473 1/20 0.60
KDM4E B2RXH2 1/20 0.59
MAPT P10636 3/20 0.54
HTT P42858 2/20 0.54
NPC1 O15118 2/20 0.54
RAB9A P51151 2/20 0.54
NPSR1 Q6W5P4 2/20 0.53
LMNA P02545 1/20 0.53
HPGD P15428 2/20 0.51
AOX1 Q06278 1/20 0.51
TRIM24 O15164 1/20 0.51
ALDH5A1 P51649 1/20 0.51
ABAT P80404 1/20 0.51
TDP1 Q9NUW8 1/20 0.51
TRIM33 Q9UPN9 1/20 0.51
CYP2C9 P11712 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2559063 0.94 ALDH1A1 (0.60) FDPSALDH1A1SMN1; SMN2POLBTSHR
SCHEMBL2558342 0.87 ALDH1A1 (0.68) FDPSALDH1A1SMN1; SMN2POLBKDM4E
SCHEMBL5789086 0.87 ALDH1A1 (0.67) FDPSALDH1A1SMN1; SMN2POLBTSHR
SCHEMBL2561250 0.85 FDPS (0.65) FDPSALDH1A1SMN1; SMN2POLBTSHR
SCHEMBL6536289 0.82 POLB (0.74) FDPSALDH1A1SMN1; SMN2POLBTSHR
SCHEMBL18095848 0.82 ALDH1A1 (0.72) FDPSALDH1A1SMN1; SMN2POLBTSHR
SCHEMBL29956894 0.82 ALDH1A1 (0.43) FDPSALDH1A1SMN1; SMN2POLBTSHR
SCHEMBL2554357 0.82 ALDH1A1 (0.58) FDPSALDH1A1SMN1; SMN2POLBTSHR
SCHEMBL2560176 0.81 ALDH1A1 (0.44) FDPSALDH1A1SMN1; SMN2POLBTSHR
SCHEMBL2284391 0.81 ALDH1A1 (0.74) FDPSALDH1A1SMN1; SMN2POLBTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed