Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 8/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.45 |
| ▸ | LMNA | P02545 | 6/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | RECQL | P46063 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15331093 | 0.86 | SMN1; SMN2 (0.47) | SMN1; SMN2MAPK1MAPTALDH1A1LMNA | |
| SCHEMBL2558565 | 0.83 | RAB9A (0.43) | SMN1; SMN2MAPK1MAPTALDH1A1LMNA | |
| SCHEMBL15332125 | 0.83 | LMNA (0.46) | SMN1; SMN2MAPK1MAPTALDH1A1LMNA | |
| SCHEMBL15333258 | 0.83 | LMNA (0.45) | SMN1; SMN2MAPK1MAPTALDH1A1LMNA | |
| SCHEMBL11728399 | 0.81 | SMN1; SMN2 (0.50) | SMN1; SMN2MAPK1MAPTALDH1A1LMNA | |
| SCHEMBL2560420 | 0.81 | LMNA (0.51) | SMN1; SMN2MAPK1MAPTALDH1A1LMNA | |
| SCHEMBL15330305 | 0.80 | RAB9A (0.43) | SMN1; SMN2MAPK1MAPTALDH1A1LMNA | |
| SCHEMBL15332337 | 0.80 | RAB9A (0.47) | SMN1; SMN2MAPK1MAPTALDH1A1LMNA | |
| SCHEMBL2557789 | 0.80 | SMN1; SMN2 (0.46) | SMN1; SMN2MAPK1MAPTALDH1A1LMNA | |
| SCHEMBL1267498 | 0.79 | SMN1; SMN2 (0.66) | SMN1; SMN2MAPK1MAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| US-11225655-B2 | Bi-functional complexes and methods for making and using such complexes | NUEVOLUTION A/S (DK) | 2022-01-18 | — | — | US | disclosed |
| EP-3540059-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | Nuevolution A/S (DK) | 2019-09-18 | — | — | EP | disclosed |
| EP-2558577-B1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION AS (DK) | 2018-12-12 | — | — | EP | disclosed |
| US-20130281324-A1 | BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2013-10-24 | — | — | US | disclosed |