Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.66 |
| ▸ | MAPT | P10636 | 8/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.62 |
| ▸ | LMNA | P02545 | 6/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.62 |
| ▸ | RECQL | P46063 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 6/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15329692 | 0.87 | MAPT (0.54) | SMN1; SMN2MAPTALDH1A1LMNANPSR1 | |
| SCHEMBL11384692 | 0.87 | MAPT (0.56) | SMN1; SMN2MAPTALDH1A1LMNANPSR1 | |
| SCHEMBL11380421 | 0.86 | KMT2A (0.59) | SMN1; SMN2MAPTALDH1A1LMNANPSR1 | |
| SCHEMBL29954298 | 0.85 | SMN1; SMN2 (0.49) | SMN1; SMN2MAPTALDH1A1LMNANPSR1 | |
| SCHEMBL2563212 | 0.84 | KMT2A (0.49) | SMN1; SMN2MAPTALDH1A1LMNANPSR1 | |
| SCHEMBL28522554 | 0.84 | SMN1; SMN2 (0.54) | SMN1; SMN2MAPTALDH1A1LMNANPSR1 | |
| SCHEMBL15332484 | 0.84 | MAPT (0.53) | SMN1; SMN2MAPTALDH1A1LMNANPSR1 | |
| SCHEMBL15329669 | 0.84 | POLB (0.55) | SMN1; SMN2MAPTALDH1A1LMNANPSR1 | |
| SCHEMBL1779819 | 0.83 | HTT (0.64) | SMN1; SMN2MAPTALDH1A1LMNANPSR1 | |
| SCHEMBL15329611 | 0.82 | MAPT (0.48) | SMN1; SMN2MAPTALDH1A1LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 192 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113105433-B | Heterocyclic compound containing pyrazole ring and quinoline ring, preparation method and application thereof | 淮阴师范学院 | 2022-05-31 | — | — | CN | claimed |
| CN-113105433-A | Heterocyclic compound containing pyrazole ring and quinoline ring, preparation method and application thereof | 淮阴师范学院 | 2021-07-13 | — | — | CN | claimed |
| CN-110642864-B | Spiro [ indazole-pyrazoline ] derivative containing pyrazole structure and preparation method and application thereof | 绍兴文理学院 | 2021-06-25 | — | — | CN | claimed |
| CN-110746431-B | P-methylmercapto phenyl substituted spiro [ indazole-pyrazoline ] derivative containing pyrazole structure and preparation method and application thereof | 绍兴文理学院 | 2021-06-18 | — | — | CN | claimed |
| CN-110734442-B | 3,4, 5-trimethoxyphenyl substituted spiro [ indazole-pyrazoline ] derivative containing pyrazole structure, and preparation method and application thereof | 绍兴文理学院 | 2021-03-09 | — | — | CN | claimed |
| CN-110790769-B | P-methylphenyl substituted spiro [ indazole-pyrazoline ] derivative containing pyrazole structure and preparation method and application thereof | 绍兴文理学院 | 2021-03-09 | — | — | CN | claimed |
| CN-110655522-B | O-chlorophenyl substituted spiro [ indazole-pyrazoline ] derivative containing pyrazole structure and preparation method and application thereof | 绍兴文理学院 | 2021-02-09 | — | — | CN | claimed |
| CN-110724148-B | P-chlorophenyl substituted spiro [ indazole-pyrazoline ] derivative containing pyrazole structure and preparation method and application thereof | 绍兴文理学院 | 2021-02-09 | — | — | CN | claimed |
| CN-108752277-B | Safe preparation method of 1- (3-methyl-1-phenyl-1H-pyrazol-5-yl) piperazine | 浙江理工大学 | 2020-11-24 | — | — | CN | claimed |
| CN-108147997-B | Pyrazole aldehyde aniline Schiff base compound and preparation method and application thereof | 淮阴师范学院 | 2020-07-10 | — | — | CN | claimed |
| CN-108752365-B | A kind of spiral shell [indolizine-isoxazoline] derivative and the preparation method and application thereof containing pyrrazole structure | 绍兴文理学院 | 2019-10-18 | — | — | CN | claimed |
| CN-108484639-B | A kind of pair of fluorine replaces spiral shell [indolizine-isoxazoline] derivative and the preparation method and application thereof containing pyrrazole structure | 绍兴文理学院 | 2019-10-18 | — | — | CN | claimed |
| CN-108752364-B | Spiral shell [indolizine-isoxazoline] derivative and the preparation method and application thereof of a kind of pair of methoxy substitution containing pyrrazole structure | 绍兴文理学院 | 2019-10-15 | — | — | CN | claimed |
| CN-108640930-B | A kind of pair of chlorine replaces spiral shell [indolizine-isoxazoline] derivative and the preparation method and application thereof containing pyrrazole structure | 绍兴文理学院 | 2019-09-10 | — | — | CN | claimed |
| CN-108640929-B9 | 3,4, 5-trimethoxy substituted spiro [ indolizine-isoxazoline ] derivative containing pyrazole structure and preparation method and application thereof | 绍兴文理学院 | 2019-09-06 | — | — | CN | claimed |
| CN-108640929-B | Spiral shell [indolizine-isoxazoline] derivative and preparation method and application of the substitution of 3,4,5- trimethoxy containing pyrrazole structure | 绍兴文理学院 | 2019-07-26 | — | — | CN | claimed |
| US-9518048-B2 | Process for the preparation of teneligliptin | GLENMARK PHARMACEUTICALS LIMITED (IN) | 2016-12-13 | — | — | US | claimed |
| US-20150203484-A1 | PROCESS FOR THE PREPARATION OF TENELIGLIPTIN | GLENMARK GENERICS LIMITED (IN) | 2015-07-23 | — | — | US | claimed |
| WO-2014041560-A2 | PROCESS FOR THE PREPARATION OF TENELIGLIPTIN | GLENMARK PHARMACEUTICALS LIMITED; GLENMARK GENERICS LIMITED (IN) | 2014-03-20 | — | — | WO | claimed |
| US-20040132807-A1 | Aurones as telomerase inhibitors | PHARMACIA ITALIA SPA (IT) | 2004-07-08 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150203484-A1 | PROCESS FOR THE PREPARATION OF TENELIGLIPTIN | VIP, TMPRSS15, SI | SMN1; SMN2 2072/4885MAPT 1756/4885ALDH1A1 4017/4885 |
| US-20040132807-A1 | Aurones as telomerase inhibitors | TERT, TERF2, TERF2IP | SMN1; SMN2 2455/4885MAPT 1433/4885ALDH1A1 1344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.