SCHEMBL15330366

SCHEMBL15330366

O=Cc1ccc(-c2cc(Cl)ccc2C(=O)O)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.49
TSHR P16473 2/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
TP53 P04637 1/20 0.49
CASP1 P29466 1/20 0.49
CA1 P00915 1/20 0.47
CA2 P00918 1/20 0.47
HSD17B10 Q99714 3/20 0.47
GRIK1 P39086 2/20 0.43
SRD5A2 P31213 1/20 0.42
KDM4E B2RXH2 1/20 0.41
SERPINE1 P05121 1/20 0.40
GAA P10253 2/20 0.40
HPGD P15428 2/20 0.40
PTGES O14684 1/20 0.40
ALOX5 P09917 1/20 0.40
CYP2C9 P11712 1/20 0.40
CASP7 P55210 1/20 0.40
HIF1A Q16665 1/20 0.40
LTB4R Q15722 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL809394 0.86 ALDH1A1 (0.59) ALDH1A1TSHRSMN1; SMN2TP53CASP1
SCHEMBL2560114 0.83 TRIM24 (0.51) ALDH1A1TSHRSMN1; SMN2TP53CASP1
SCHEMBL30522317 0.83 ALDH1A1 (0.52) ALDH1A1SMN1; SMN2HSD17B10KDM4EKMT2A
SCHEMBL29044828 0.82 ALDH1A1 (0.58) ALDH1A1HSD17B10KDM4EHPGDMAPT
SCHEMBL7554300 0.81 ALDH1A1 (0.57) ALDH1A1TSHRSMN1; SMN2TP53CASP1
SCHEMBL2562681 0.81 PTGS1 (0.45) ALDH1A1CA1CA2HSD17B10KDM4E
SCHEMBL6492374 0.80 DHODH (0.55) ALDH1A1TSHRSMN1; SMN2TP53CASP1
SCHEMBL8248300 0.78 ALDH1A1 (0.68) ALDH1A1TSHRSMN1; SMN2TP53CASP1
SCHEMBL6695209 0.77 PRKAB2 (0.53) ALDH1A1TSHRSMN1; SMN2TP53CASP1
SCHEMBL2558658 0.77 AKR1C3 (0.51) ALDH1A1TSHRSMN1; SMN2TP53CASP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed