SCHEMBL15331663

SCHEMBL15331663

O=Cc1c[nH]c2ccc(-c3ccc(Cl)c(F)c3)cc12

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.48
CYP1A2 P05177 1/20 0.48
CYP2C19 P33261 1/20 0.48
CYP2A6 P11509 2/20 0.45
IMPDH2 P12268 1/20 0.45
ICMT O60725 1/20 0.44
PIM3 Q86V86 3/20 0.44
PIM1 P11309 1/20 0.44
CCNT1 O60563 1/20 0.42
CDK9 P50750 1/20 0.42
HASPIN Q8TF76 1/20 0.42
CAPN1 P07384 1/20 0.40
CAPN2 P17655 1/20 0.40
KDM4E B2RXH2 1/20 0.38
MAPT P10636 1/20 0.38
ESR1 P03372 1/20 0.38
ESR2 Q92731 1/20 0.38
HDAC6 Q9UBN7 1/20 0.37
GABRP O00591 1/20 0.37
GABRD O14764 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2535403 0.82 PIM1 (0.53) ALDH1A1CYP1A2CYP2C19CYP2A6IMPDH2
SCHEMBL15330695 0.82 ALDH1A1 (0.53) ALDH1A1CYP1A2CYP2C19CYP2A6IMPDH2
SCHEMBL6219478 0.80 ALDH1A1 (0.58) ALDH1A1CYP1A2CYP2C19CYP2A6IMPDH2
SCHEMBL3459734 0.79 CYP2A6 (0.61) ALDH1A1CYP1A2CYP2C19CYP2A6IMPDH2
SCHEMBL29955727 0.79 GPR84 (0.56) ALDH1A1CYP1A2CYP2C19CYP2A6IMPDH2
SCHEMBL15392978 0.79 CYP2A6 (0.47) ALDH1A1CYP1A2CYP2C19CYP2A6IMPDH2
SCHEMBL1248749 0.79 GPR84 (0.56) ALDH1A1CYP1A2CYP2C19CYP2A6IMPDH2
SCHEMBL15330818 0.78 ICMT (0.55) ALDH1A1CYP1A2CYP2C19CYP2A6IMPDH2
SCHEMBL15330606 0.78 CYP2A6 (0.50) ALDH1A1CYP1A2CYP2C19CYP2A6IMPDH2
SCHEMBL2531595 0.77 CYP2A6 (0.61) ALDH1A1CYP1A2CYP2C19CYP2A6IMPDH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed