Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | TYMS | P04818 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.33 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | TDP2 | O95551 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15333708 | 0.77 | MAPT (0.45) | MAPTKDM4EL3MBTL1ALDH1A1NPC1 | |
| SCHEMBL6767399 | 0.77 | MAPT (0.42) | MAPTKDM4EL3MBTL1ALDH1A1TYMS | |
| SCHEMBL15340739 | 0.77 | MAPT (0.45) | MAPTKDM4EL3MBTL1ALDH1A1NPC1 | |
| SCHEMBL24842 | 0.77 | MAPT (0.39) | MAPTALDH1A1NPC1KMT2AMEN1 | |
| SCHEMBL17190976 | 0.76 | L3MBTL1 (0.59) | MAPTL3MBTL1HPGDALDH1A1NPC1 | |
| SCHEMBL17190983 | 0.73 | ALDH1A1 (0.56) | MAPTL3MBTL1HPGDALDH1A1NPC1 | |
| SCHEMBL13167840 | 0.73 | ALDH1A1 (0.56) | MAPTL3MBTL1HPGDALDH1A1NPC1 | |
| SCHEMBL6773082 | 0.72 | MAPT (0.43) | MAPTKDM4EL3MBTL1ALDH1A1NPC1 | |
| SCHEMBL3287587 | 0.71 | PARP1 (0.41) | MAPTKDM4ETYMSNPC1KMT2A | |
| SCHEMBL3287590 | 0.71 | PARP1 (0.41) | MAPTKDM4ETYMSNPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2661426-B1 | PYRAZOL-4-YL CARBOXAMIDE DERIVATIVES AS MICROBIOCIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2014-08-27 | — | — | EP | disclosed |
| US-8653003-B2 | Pyrazol-4-yl carboxamide derivatives as microbiocides | SYNGENTA PARTICIPATIONS AG (CH) | 2014-02-18 | — | — | US | disclosed |
| US-8653003-B2 | Pyrazol-4-yl carboxamide derivatives as microbiocides | SYNGENTA PARTICIPATIONS AG (CH) | 2014-02-18 | — | — | US | disclosed |
| US-20130281505-A1 | PYRAZOL-4-YL CARBOXAMIDE DERIVATIVES AS MICROBIOCIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2013-10-24 | — | — | US | disclosed |
| US-20130281505-A1 | PYRAZOL-4-YL CARBOXAMIDE DERIVATIVES AS MICROBIOCIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2013-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130281505-A1 | PYRAZOL-4-YL CARBOXAMIDE DERIVATIVES AS MICROBIOCIDES | C3AR1, CD209, CCR9 | MAPT 3643/4885KDM4E 3577/4885L3MBTL1 432/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.