Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.43 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.39 |
| ▸ | AR | P10275 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1534523 | 0.82 | ABCG2 (0.43) | ABCG2DDR2SMN1; SMN2ABCC1CYP1B1 | |
| SCHEMBL29129586 | 0.82 | ABCG2 (0.43) | ABCG2DDR2SMN1; SMN2ABCC1CYP1B1 | |
| SCHEMBL1534501 | 0.78 | MAOA (0.57) | ABCG2SMN1; SMN2ABCC1CYP1B1KDM4E | |
| SCHEMBL1534379 | 0.77 | AR (0.51) | ABCG2DDR2CYP1B1ARKDM4E | |
| SCHEMBL19846954 | 0.76 | SMN1; SMN2 (0.41) | ABCG2DDR2SMN1; SMN2ABCC1CYP1B1 | |
| SCHEMBL1534478 | 0.76 | ACHE (0.49) | ABCG2DDR2SMN1; SMN2CYP1B1AR | |
| SCHEMBL1423181 | 0.76 | KMT2A (0.65) | ABCG2DDR2SMN1; SMN2CYP1B1AR | |
| Hydrochloric Acid SCHEMBL28357420 | 0.75 | SMN1; SMN2 (0.40) | ABCG2DDR2SMN1; SMN2ABCC1CYP1B1 | |
| SCHEMBL1534580 | 0.75 | MAPT (0.41) | ABCG2DDR2ABCC1CYP1B1AR | |
| SCHEMBL8815403 | 0.74 | ATP1A1 (0.47) | SMN1; SMN2KDM4ECYP3A4CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8546376-B2 | Pharmaceutical compounds | ALMAC DISCOVERY LIMITED (GB) | 2013-10-01 | — | — | US | disclosed |
| US-20120238541-A1 | PHARMACEUTICAL COMPOUNDS | ALMAC DISCOVERY LIMITED (GB) | 2012-09-20 | — | — | US | disclosed |
| EP-2473495-A1 | PHARMACEUTICAL COMPOUNDS | Almac Discovery Limited (GB) | 2012-07-11 | — | — | EP | disclosed |
| WO-2011033265-A1 | PHARMACEUTICAL COMPOUNDS | ALMAC DISCOVERY LIMITED (GB) | 2011-03-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120238541-A1 | PHARMACEUTICAL COMPOUNDS | PIK3CA, PLK1, MTOR | ABCG2 507/4885DDR2 1548/4885SMN1; SMN2 2863/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.