Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
| ▸ | CCR8 | P51685 | 1/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.40 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | BCR | P11274 | 2/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 2/20 | 0.36 |
| ▸ | KHK | P50053 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15341725 | 0.85 | IRAK4 (0.37) | NR3C1IRAK4TRPA1PGR | |
| SCHEMBL15344156 | 0.80 | CCR1 (0.47) | CYP2A6CCR1CCR5CCR8IRAK4 | |
| SCHEMBL15345153 | 0.80 | CCR1 (0.43) | CYP2A6CCR1CCR5CCR8NR3C1 | |
| SCHEMBL15345074 | 0.78 | MET (0.45) | CYP2A6CCR1CCR5CCR8NR3C1 | |
| SCHEMBL15345150 | 0.77 | CCR1 (0.43) | CYP2A6CCR1CCR5CCR8NR3C1 | |
| SCHEMBL15345073 | 0.75 | CYP2A6 (0.41) | CYP2A6CCR1CCR5CCR8NR3C1 | |
| SCHEMBL15345149 | 0.75 | GPR119 (0.44) | CYP2A6CCR1CCR5CCR8NR3C1 | |
| SCHEMBL15345044 | 0.72 | CYP2A6 (0.39) | CYP2A6CCR1CCR5CCR8NR3C1 | |
| SCHEMBL15345070 | 0.72 | CYP2A6 (0.39) | CYP2A6CCR1CCR5CCR8NR3C1 | |
| SCHEMBL15344155 | 0.71 | IRAK4 (0.48) | CYP2A6CCR1CCR5CCR8IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3070081-B1 | BENZOTHIAZOL-6-YL ACETIC ACID DERIVATIVES AND THEIR USE FOR TREATING AN HIV INFECTION | GILEAD SCIENCES INC (US) | 2018-02-28 | — | — | EP | disclosed |
| US-20160015690-A1 | THERAPEUTIC COMPOUNDS | GILEAD SCIENCES, INC. | 2016-01-21 | — | — | US | disclosed |
| US-8987250-B2 | Therapeutic compounds | GILEAD SCIENCES, INC. (US) | 2015-03-24 | — | — | US | disclosed |
| US-20130281433-A1 | THERAPEUTIC COMPOUNDS | GILEAD SCIENCES, INC. | 2013-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160015690-A1 | THERAPEUTIC COMPOUNDS | NQO1, HAVCR2, CCR5 | CYP2A6 855/4885CCR1 106/4885CCR5 3/4885 |
| US-20130281433-A1 | THERAPEUTIC COMPOUNDS | NQO1, HAVCR2, CCR5 | CYP2A6 855/4885CCR1 106/4885CCR5 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.