Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 5/20 | 0.55 |
| ▸ | GABRD | O14764 | 5/20 | 0.55 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.55 |
| ▸ | GABRB1 | P18505 | 5/20 | 0.55 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.55 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.55 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.55 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.55 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.55 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.55 |
| ▸ | GABRA4 | P48169 | 5/20 | 0.55 |
| ▸ | GABRE | P78334 | 5/20 | 0.55 |
| ▸ | GABRA6 | Q16445 | 5/20 | 0.55 |
| ▸ | GABRG1 | Q8N1C3 | 5/20 | 0.55 |
| ▸ | GABRG3 | Q99928 | 5/20 | 0.55 |
| ▸ | GABRQ | Q9UN88 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1534705 | 0.88 | BCHE (0.51) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL30876960 | 0.82 | MAPT (0.70) | KMT2ABCHEACHEKDM4ESMN1; SMN2 | |
| SCHEMBL1534381 | 0.82 | TNKS (0.55) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL28555552 | 0.82 | CYP3A4 (0.51) | KMT2AKDM4ESMN1; SMN2LMNAADORA3 | |
| SCHEMBL1423181 | 0.81 | KMT2A (0.65) | KMT2AKDM4ESMN1; SMN2LMNAADORA3 | |
| SCHEMBL1534543 | 0.79 | ALDH1A1 (0.74) | KMT2AKDM4ESMN1; SMN2LMNAADORA3 | |
| SCHEMBL28899237 | 0.78 | GABRP (0.50) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL29259000 | 0.78 | GABRP (0.50) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL1534478 | 0.78 | ACHE (0.49) | KMT2ABCHEACHEKDM4ESMN1; SMN2 | |
| SCHEMBL4572496 | 0.77 | GABRP (0.59) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8546376-B2 | Pharmaceutical compounds | ALMAC DISCOVERY LIMITED (GB) | 2013-10-01 | — | — | US | disclosed |
| US-20120238541-A1 | PHARMACEUTICAL COMPOUNDS | ALMAC DISCOVERY LIMITED (GB) | 2012-09-20 | — | — | US | disclosed |
| EP-2473495-A1 | PHARMACEUTICAL COMPOUNDS | Almac Discovery Limited (GB) | 2012-07-11 | — | — | EP | disclosed |
| WO-2011033265-A1 | PHARMACEUTICAL COMPOUNDS | ALMAC DISCOVERY LIMITED (GB) | 2011-03-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120238541-A1 | PHARMACEUTICAL COMPOUNDS | PIK3CA, PLK1, MTOR | GABRP 3303/4885GABRD 4300/4885GABRA1 4123/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.