Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.47 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.47 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MC4R | P32245 | 1/20 | 0.44 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.37 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8569230 | 1.00 | LMNA (0.49) | LMNASMN1; SMN2CYP2D6HTTMAPT | |
| SCHEMBL14577512 | 1.00 | LMNA (0.49) | LMNASMN1; SMN2CYP2D6HTTMAPT | |
| SCHEMBL27646763 | 1.00 | LMNA (0.49) | LMNASMN1; SMN2CYP2D6HTTMAPT | |
| SCHEMBL8565182 | 1.00 | LMNA (0.49) | LMNASMN1; SMN2CYP2D6HTTMAPT | |
| SCHEMBL8576385 | 1.00 | LMNA (0.49) | LMNASMN1; SMN2CYP2D6HTTMAPT | |
| SCHEMBL8580577 | 1.00 | LMNA (0.49) | LMNASMN1; SMN2CYP2D6HTTMAPT | |
| SCHEMBL9682060 | 0.88 | CYP2D6 (0.50) | LMNASMN1; SMN2CYP2D6HTTMAPT | |
| SCHEMBL14026665 | 0.82 | CYP2D6 (0.55) | LMNASMN1; SMN2CYP2D6HTTMAPT | |
| SCHEMBL10280648 | 0.82 | CYP2D6 (0.55) | LMNASMN1; SMN2CYP2D6HTTMAPT | |
| SCHEMBL19895486 | 0.81 | CYP2D6 (0.44) | LMNASMN1; SMN2CYP2D6HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130303551-A1 | PYRIMIDINONE DERIVATIVES AS FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC | 2013-11-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130303551-A1 | PYRIMIDINONE DERIVATIVES AS FATTY ACID SYNTHASE INHIBITORS | FASN, FPGS, DHPS | LMNA 3065/4885SMN1; SMN2 3941/4885CYP2D6 720/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.