Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | MC4R | P32245 | 1/20 | 0.45 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.38 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27646763 | 0.88 | LMNA (0.49) | CYP2D6MC4RCCR5LMNASMN1; SMN2 | |
| SCHEMBL14577512 | 0.88 | LMNA (0.49) | CYP2D6MC4RCCR5LMNASMN1; SMN2 | |
| SCHEMBL15380683 | 0.88 | LMNA (0.49) | CYP2D6MC4RCCR5LMNASMN1; SMN2 | |
| SCHEMBL8565182 | 0.88 | LMNA (0.49) | CYP2D6MC4RCCR5LMNASMN1; SMN2 | |
| SCHEMBL8569230 | 0.88 | LMNA (0.49) | CYP2D6MC4RCCR5LMNASMN1; SMN2 | |
| SCHEMBL8576385 | 0.88 | LMNA (0.49) | CYP2D6MC4RCCR5LMNASMN1; SMN2 | |
| SCHEMBL8580577 | 0.88 | LMNA (0.49) | CYP2D6MC4RCCR5LMNASMN1; SMN2 | |
| SCHEMBL9681972 | 0.84 | CYP2D6 (0.47) | CYP2D6MC4RCCR5LMNASMN1; SMN2 | |
| SCHEMBL5968996 | 0.83 | OPRD1 (0.43) | CYP2D6LMNAOPRM1OPRD1OPRK1 | |
| SCHEMBL9682517 | 0.78 | CYP2D6 (0.55) | CYP2D6MC4RCCR5OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130309-A | Cardiovascular disorders | A. H. ROBINS COMPANY, INCORPORATED (US) | 1992-07-14 | — | — | US | disclosed |