Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.49 |
| ▸ | CDK8 | P49336 | 7/20 | 0.47 |
| ▸ | CDK7 | P50613 | 2/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.47 |
| ▸ | CCND1 | P24385 | 1/20 | 0.47 |
| ▸ | CCNC | P24863 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | CCNH | P51946 | 1/20 | 0.47 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.47 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | AXL | P30530 | 2/20 | 0.41 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetamide SCHEMBL9934069 | 0.93 | RIPK1 (0.47) | RIPK1CDK8CDK7CCNT1CCND1 | |
| SCHEMBL64925 | 0.90 | — | — | |
| SCHEMBL29407705 | 0.90 | — | — | |
| SCHEMBL2078432 | 0.90 | AXL (0.48) | RIPK1CDK8CDK7CCNT1CCND1 | |
| Hydrochloric Acid SCHEMBL310786 | 0.88 | AXL (0.47) | RIPK1CDK8CDK7CCNT1CCND1 | |
| Hydrochloric Acid SCHEMBL31308615 | 0.88 | AXL (0.47) | RIPK1CDK8CDK7CCNT1CCND1 | |
| Hydrochloric Acid SCHEMBL311520 | 0.88 | AXL (0.47) | RIPK1CDK8CDK7CCNT1CCND1 | |
| SCHEMBL7500296 | 0.88 | AXL (0.47) | RIPK1CDK8CDK7CCNT1CCND1 | |
| SCHEMBL3845938 | 0.88 | AXL (0.47) | RIPK1CDK8CDK7CCNT1CCND1 | |
| SCHEMBL15880172 | 0.87 | AXL (0.42) | RIPK1CDK8CDK7CCNT1CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130303563-A1 | TREATMENT OF PERITONEAL INJURY USING JAK INHIBITORS | LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER | 2013-11-14 | — | — | US | claimed |
| EP-3600440-A1 | REDUCED EXPOSURE CONJUGATES MODULATING THERAPEUTIC TARGETS | Sienna Biopharmaceuticals, Inc. (US) | 2020-02-05 | — | — | EP | disclosed |
| WO-2020023389-A1 | REDUCED EXPOSURE COMPOSITIONS MODULATING THERAPEUTIC TARGETS | SIENNA BIOPHARMACEUTICALS, INC. (US) | 2020-01-30 | — | — | WO | disclosed |
| WO-2018175315-A1 | POLYMER CONJUGATES OF STAUROSPORINE DERIVATIVES HAVING REDUCED EXPOSURE | SIENNA BIOPHARMACEUTICALS, INC. (US) | 2018-09-27 | — | — | WO | disclosed |
| WO-2018175340-A1 | REDUCED EXPOSURE CONJUGATES MODULATING THERAPEUTIC TARGETS | SIENNA BIOPHARMACEUTICALS, INC. (US) | 2018-09-27 | — | — | WO | disclosed |
| US-9198900-B2 | Treatment of peritoneal injury using JAK inhibitors | LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER (US) | 2015-12-01 | — | — | US | disclosed |
| US-20130303563-A1 | TREATMENT OF PERITONEAL INJURY USING JAK INHIBITORS | LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER | 2013-11-14 | — | — | US | disclosed |
| CN-102822177-A | Pyrrolo [ 2, 3 - d] pyrimidine urea compounds as jak inhibitors | PFIZER | 2012-12-12 | — | — | CN | disclosed |
| CN-102822177-A | Pyrrolo [ 2, 3 - d] pyrimidine urea compounds as jak inhibitors | PFIZER | 2012-12-12 | — | — | CN | disclosed |