PRUNE1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL25488768	0.52	2/20
SCHEMBL16094288	0.43	2/20
SCHEMBL20020052	0.43	2/20
Hydrochloric Acid (SCHEMBL17494537)	0.43	2/20
SCHEMBL25196291	0.41	2/20
SCHEMBL9668239	0.41	2/20
SCHEMBL30066743	0.41	2/20
SCHEMBL25188264	0.38	2/20
SCHEMBL17857263	0.37	2/20
SCHEMBL25193224	0.36	2/20
SCHEMBL3682526	0.70	1/20
SCHEMBL1394958	0.69	1/20
SCHEMBL3682525	0.67	1/20
SCHEMBL5827744	0.67	1/20
SCHEMBL27221084	0.62	1/20
SCHEMBL7971734	0.60	1/20
SCHEMBL7960337	0.59	1/20
SCHEMBL15619030	0.58	1/20
SCHEMBL3106797	0.57	1/20
SCHEMBL25196808	0.56	1/20

Clinical trials — most relevant to PRUNE1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Genetic and Functional Analysis of Cherubism	nan	RECRUITING
Young Pectus Excavatum Patients and Genetic Defects	nan	COMPLETED
Whole Exome Sequencing in Coronary Artery Ectasia	nan	COMPLETED
Screening for Genes in Patients With Poikiloderma	nan	COMPLETED
Risk Burden of Lipoprotein Metabolic Gene Haplotypes	nan	COMPLETED
Parkinson's Foundation PD GENEration Genetic Registry	nan	RECRUITING
Genetic Basis of Mitral Valve Prolapse	nan	UNKNOWN
PCD New Gene Discovery	nan	COMPLETED
Chest Wall Deformities in Children - Epidemiological Data	nan	COMPLETED
Pathogenetic Basis of Aortopathy and Aortic Valve Disease	nan	ACTIVE_NOT_RECRUITING
Nutritional Ketosis: a Novel Metabolic Strategy to Treat Lymphedema Patients?	nan	RECRUITING
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives	nan	UNKNOWN
Hypospadias and Exome: Identification of New Genes for Familial Hypospadias	nan	COMPLETED
Search for Genes Influencing Childhood Absence Epilepsy (CAE) Study	nan	COMPLETED
Gene Mutations and Orthopaedic Symptoms Correlation of Multiple Hereditary Exostoses: Multicentre Project	nan	SUSPENDED
Investigation of the Genetic Causes of Kallmann Syndrome and Reproductive Disorders	nan	COMPLETED
Genetic Basis of Abdominal Aortic Aneurysm	nan	COMPLETED
Familial Intracranial Aneurysm Study II	nan	COMPLETED
Identification of New Genes Implicated in Rare Neurosensory Diseases by Whole Exome Sequencing	nan	UNKNOWN
Identification of Genes and Pathogenesis Involved in Familial Thoracic Aortic Aneurysm	nan	COMPLETED
Genetic Analysis of Parkinson's Disease	nan	COMPLETED
New Genes Involved in Molecular Etiology of Rett Syndrome Through DNA Microarray Comparative Genomic Hybridization	nan	COMPLETED
Gene Mutations and Rescue in Human Congenital Diaphragmatic Hernia	nan	UNKNOWN
Implementation of Molecular Diagnostic Pathways	nan	UNKNOWN
Mapping Novel Disease Genes for Dilated Cardiomyopathy	nan	COMPLETED
Genetic Analysis of Inherited Urologic Malignant Disorders: Collection of Samples	nan	COMPLETED
Genetics and Psychopathology in the 22q11 Deletion Syndrome	nan	UNKNOWN
Clinical and Genetic Analysis in Congenital Hypothyroidism Due to Thyroid Dysgenesis.	nan	COMPLETED
Monogenic Diabetes Misdiagnosed as Type 1	nan	RECRUITING
Study on Moebius Syndrome and Congenital Facial Weakness Disorders	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a PRUNE1 binder may also engage these)

Protein	Name	Similarity
Q6AYG3	—	1.000	Q6AYG3 →
Q5E9Y6	—	0.997	Q5E9Y6 →
Q8BIW1	—	0.996	Q8BIW1 →
Q4FZX0	—	0.969	Q4FZX0 →
Q5RL51	—	0.969	Q5RL51 →
Q0GNC1	—	0.967	Q0GNC1 →
Q8NE28	—	0.967	Q8NE28 →
Q9R144	—	0.966	Q9R144 →
Q4KLN4	—	0.966	Q4KLN4 →
B2RUP2	—	0.966	B2RUP2 →
Q5RJK3	—	0.966	Q5RJK3 →
Q5T7W7	—	0.966	Q5T7W7 →
Q5JPI3	—	0.965	Q5JPI3 →
Q08DP1	—	0.965	Q08DP1 →
Q4R6Y8	—	0.965	Q4R6Y8 →
A1IGU4	—	0.965	A1IGU4 →
Q96NW4	—	0.965	Q96NW4 →
PARP4	Protein mono-ADP-ribosyltransferase PARP4	0.964	landscape →
E1BCH6	—	0.964	E1BCH6 →
Q6PF06	—	0.964	Q6PF06 →
Q5REW9	—	0.964	Q5REW9 →
Q8NEC7	—	0.964	Q8NEC7 →
Q14CH1	—	0.964	Q14CH1 →
Q9Y2M0	—	0.963	Q9Y2M0 →
Q5R5S1	—	0.963	Q5R5S1 →
Q3UMR0	—	0.963	Q3UMR0 →
Q3U269	—	0.963	Q3U269 →
O94952	—	0.963	O94952 →
A0JPF9	—	0.963	A0JPF9 →
DCLRE1B	5' exonuclease Apollo	0.963	landscape →