Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.62 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | TP53 | P04637 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.47 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TYR | P14679 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1821573 | 0.78 | CYP1A1 (0.75) | MEN1KMT2ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL30557661 | 0.78 | CYP1A1 (0.75) | MEN1KMT2ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7403707 | 0.77 | RAB9A (0.68) | MEN1KMT2ASMN1; SMN2KDM4ETP53 | |
| SCHEMBL11137533 | 0.76 | MAPT (0.50) | MEN1KMT2APARP1SMN1; SMN2KDM4E | |
| SCHEMBL14085522 | 0.75 | TP53 (0.49) | MEN1KMT2ASMN1; SMN2KDM4ETP53 | |
| SCHEMBL24358021 | 0.75 | MEN1 (0.52) | MEN1KMT2ASMN1; SMN2KDM4ETP53 | |
| SCHEMBL10486211 | 0.75 | LMNA (0.49) | MEN1KMT2ASMN1; SMN2KDM4ETP53 | |
| SCHEMBL2381338 | 0.75 | MEN1 (0.49) | MEN1KMT2ASMN1; SMN2KDM4ETP53 | |
| SCHEMBL29601739 | 0.75 | MEN1 (0.52) | MEN1KMT2ASMN1; SMN2KDM4ETP53 | |
| SCHEMBL1415660 | 0.73 | ALDH1A1 (0.60) | MEN1KMT2ASMN1; SMN2KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3424912-A1 | 2-AMINOTHIAZOLE DERIVATIVES FOR MEDICAL USE | Huazhong University of Science and Technology (CN) | 2019-01-09 | — | — | EP | disclosed |
| US-9771340-B2 | 2-aminothiazole derivatives and methods of preparing and using the same | WUHAN INNAMUNE PHARMACEUTICAL CO., LTD. (CN) | 2017-09-26 | — | — | US | disclosed |
| CN-102336720-B | Thiazolamine derivative and preparation method and application | HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2016-01-13 | — | — | CN | disclosed |
| EP-2682390-A1 | 2-AMINOTHIAZOLE DERIVATIVE, PREPARATION METHOD, AND USE | Huazhong University of Science and Technology (CN) | 2014-01-08 | — | — | EP | disclosed |
| US-20140004155-A1 | 2-AMINOTHIAZOLE DERIVATIVES AND METHODS OF PREPARING AND USING THE SAME | HANGZHOU ZHONGMEI HUADONG PHARMACEUTICAL CO., LTD. (CN) | 2014-01-02 | — | — | US | disclosed |
| CN-102336720-A | 2-aminothiazole derivatives, and preparation method and application thereof | UNIV HUAZHONG SCIENCE TECH | 2012-02-01 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140004155-A1 | 2-AMINOTHIAZOLE DERIVATIVES AND METHODS OF PREPARING AND USING THE SAME | CCNT1, CCNE1, CCNT2 | MEN1 847/4885KMT2A 188/4885PARP1 1672/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.