SCHEMBL15401890

SCHEMBL15401890

NC1(c2ccc(Br)cc2)CC(O)(C2CC2)C1

nearest known ligand 0.39

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AKT1 P31749 19/20 0.39
AKT2 P31751 18/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15401891 1.00 AKT1 (0.39) AKT1AKT2
SCHEMBL15401382 0.76 TAAR1 (0.39) AKT1AKT2
SCHEMBL15401384 0.76 TAAR1 (0.39) AKT1AKT2
SCHEMBL15906512 0.72 F11 (0.40) AKT1AKT2
SCHEMBL10241861 0.71 CYP2A6 (0.35)
SCHEMBL1539148 0.69 KDM1A (0.40) AKT1AKT2
SCHEMBL10226674 0.69 KDM1A (0.40) AKT1AKT2
SCHEMBL1608039 0.69 KDM1A (0.40) AKT1AKT2
SCHEMBL11950297 0.69 KMT2A (0.35)
SCHEMBL991567 0.69 CYP2A6 (0.42)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2868660-B1 ANTITUMOR EFFECT POTENTIATOR COMPRISING AN IMIDAZOOXAZINE COMPOUND TAIHO PHARMACEUTICAL CO LTD (JP) 2017-12-27 EP disclosed
US-9375434-B2 Antitumor effect potentiator composed of imidazooxazine compound TAIHO PHARMACEUTICAL CO., LTD. (JP) 2016-06-28 US disclosed
US-9289431-B2 2016-03-22 US disclosed
EP-2698372-B1 NOVEL IMIDAZO-OXAZINE COMPOUND OR SALT THEREOF TAIHO PHARMACEUTICAL CO LTD (JP) 2016-02-03 EP disclosed
US-20150164909-A1 ANTITUMOR EFFECT POTENTIATOR COMPOSED OF IMIDAZOOXAZINE COMPOUND TAIHO PHARMACEUTICAL CO., LTD. (JP) 2015-06-18 US disclosed
EP-2868660-A1 ANTITUMOR EFFECT POTENTIATOR COMPOSED OF IMIDAZOOXAZINE COMPOUND Taiho Pharmaceutical Co., Ltd. (JP) 2015-05-06 EP disclosed
US-8772283-B2 Imidazo-oxazine compound or salt thereof TAIHO PHARMACEUTICAL CO., LTD. (JP) 2014-07-08 US disclosed
EP-2698372-A1 NOVEL IMIDAZO-OXAZINE COMPOUND OR SALT THEREOF Taiho Pharmaceutical Co., Ltd. (JP) 2014-02-19 EP disclosed
US-20140005185-A1 NOVEL IMIDAZO-OXAZINE COMPOUND OR SALT THEREOF TAIHO PHARMACEUTICAL CO., LTD. (JP) 2014-01-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150164909-A1 ANTITUMOR EFFECT POTENTIATOR COMPOSED OF IMIDAZOOXAZINE COMPOUND H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HCCS, TPD52L2 AKT1 419/4885AKT2 620/4885
US-20140005185-A1 NOVEL IMIDAZO-OXAZINE COMPOUND OR SALT THEREOF IKZF3, IKZF2, IKZF1 AKT1 2351/4885AKT2 1971/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.