SCHEMBL15412264

SCHEMBL15412264

O=c1nc(NF)ccn1C1=CCCC1

nearest known ligand 0.32

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
LMNA P02545 1/20 0.32
MAPT P10636 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL594613 0.77 LMNA (0.35) LMNAMAPT
Phosphoric Acid SCHEMBL17537058 0.71 FGFR1 (0.36) LMNAMAPT
SCHEMBL4307802 0.65 LMNA (0.46) LMNAMAPT
SCHEMBL12741775 0.62 ALB (0.36)
SCHEMBL1174410 0.57 BIRC5 (0.42) LMNAMAPT
SCHEMBL18244672 0.57 CDK2 (0.46)
SCHEMBL21227587 0.55 MAPT (0.37) LMNAMAPT
SCHEMBL8054416 0.55 LMNA (0.43) LMNAMAPT
SCHEMBL15412261 0.55 LMNA (0.32) LMNAMAPT
SCHEMBL5600749 0.54 LMNA (0.37) LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118987233-A Pharmaceutical composition for treating classical hodgkin lymphoma and application thereof 武汉科技大学 2024-11-22 CN claimed
WO-2022173711-A9 METHOD OF TREATING CANCER WITH NUCLEOTIDE THERAPEUTICS MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2022-10-06 WO claimed
WO-2022173711-A1 METHOD OF TREATING CANCER WITH NUCLEOTIDE THERAPEUTICS MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2022-08-18 WO claimed
US-20220249534-A1 METHOD OF TREATING CANCER WITH NUCLEOTIDE THERAPEUTICS THE GENERAL HOSPITAL CORPORATION 2022-08-11 US claimed
CN-110051846-A A kind of antineoplastic pharmaceutical compositions and its application based on humoral immunity blocking 中山大学 2019-07-26 CN claimed
CN-109999038-A A kind of antineoplastic pharmaceutical compositions and its application based on blocking macrophage effect 中山大学 2019-07-12 CN claimed
EP-3207932-A1 DNA METHYLTRANSFERASE INHIBITORS FOR RETT SYNDROME THERAPY Universität Stuttgart (DE) 2017-08-23 EP claimed
EP-4667499-A2 INTERLEUKIN-2-FC FUSION PROTEINS AND METHODS OF USE Gilead Sciences, Inc. (US) 2025-12-24 EP disclosed
US-20250319183-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER AVIGAN DAVID (US) 2025-10-16 US disclosed
US-20250295686-A1 COMBINATION DECITABINE AND MPS1 INHIBITOR THERAPY TO PRIME CANCER IMMUNOGENICITY DANA-FARBER CANCER INSTITUTE, INC. 2025-09-25 US disclosed
EP-4232463-B1 INTERLEUKIN-2-FC FUSION PROTEINS AND METHODS OF USE GILEAD SCIENCES INC (US) 2025-09-03 EP disclosed
CN-118987233-A Pharmaceutical composition for treating classical hodgkin lymphoma and application thereof 武汉科技大学 2024-11-22 CN disclosed
EP-4419209-A1 COMBINATION DECITABINE AND MPS1 INHIBITOR THERAPY TO PRIME CANCER IMMUNOGENICITY Dana-Farber Cancer Institute, Inc. (US) 2024-08-28 EP disclosed
US-9150520-B2 Process for the preparation of 4-amino-1-((1S,4R,5S)-2-fluoro-4,5-dihydroxy-3-hydroxymethyl-cyclopent-2-enyl)-1H-pyrimidin-2-one REXAHN PHARMACEUTICALS, INC. (US) 2015-10-06 US disclosed
US-20150167004-A1 OLIGONUCLEOTIDE INHIBITORS OF DNA METHYLTRANSFERASES AND THEIR USE IN TREATING DISEASES METHEOR THERAPEUTICS CORPORATION 2015-06-18 US disclosed
EP-2869852-A2 OLIGONUCLEOTIDE INHIBITORS OF DNA METHYLTRANSFERASES AND THEIR USE IN TREATING DISEASES Metheor Therapeutics Corporation (US) 2015-05-13 EP disclosed
US-20150038548-A1 OLIGONUCLEOTIDE INHIBITORS OF DNA METHYLTRANSFERASES AND THEIR USE IN TREATING DISEASES METHEOR THERAPEUTICS CORPORATION 2015-02-05 US disclosed
WO-2014145807-A1 PROCESS FOR THE PREPARATION OF 4-AMINO-1-((1S,4R, 5S)-2-FLUORO-4,5-DIHYDROXY-3-HYDROXYMETHYL-CYCLOPENT-2-ENYL)-1H-PYRIMIDIN-2-ONE REXAHN PHARMACEUTICALS, INC. (US) 2014-09-18 WO disclosed
US-20140275537-A1 PROCESS FOR THE PREPARATION OF 4-AMINO-1-((1S,4R,5S)-2-FLUORO-4,5-DIHYDROXY-3-HYDROXYMETHYL-CYCLOPENT-2-ENYL)-1H-PYRIMIDIN-2-ONE REXAHN PHARMACEUTICALS, INC. (US) 2014-09-18 US disclosed
WO-2014011573-A2 OLIGONUCLEOTIDE INHIBITORS OF DNA METHYLTRANSFERASES AND THEIR USE IN TREATING DISEASES METHEOR THERAPEUTICS CORPORATION (US) 2014-01-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140275537-A1 PROCESS FOR THE PREPARATION OF 4-AMINO-1-((1S,4R,5S)-2-FLUORO-4,5-DIHYDROXY-3-HYDROXYMETHYL-CYCLOPENT-2-ENYL)-1H-PYRIMIDIN-2-ONE RXFP4, RXFP1, NPY4R MEN1 1273/4885KMT2A 1861/4885LMNA 3265/4885
US-20250319183-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER MCL1, BCL2, BCL3 MEN1 2632/4885KMT2A 2681/4885LMNA 1656/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.