Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 3/20 | 0.41 |
| ▸ | SLC6A3 known ✓ | Q01959 | 3/20 | 0.41 |
| ▸ | ACP3 | P15309 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ANPEP | P15144 | 2/20 | 0.39 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.39 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL197100 | 0.96 | ACP3 (0.48) | ACP3KCNH2SIGMAR1SLC6A4SLC6A2 | |
| Hydrochloric Acid SCHEMBL7165416 | 0.94 | ACP3 (0.47) | ACP3KCNH2SIGMAR1SLC6A4SLC6A2 | |
| SCHEMBL1398395 | 0.94 | ACP3 (0.47) | ACP3KCNH2SIGMAR1SLC6A4SLC6A2 | |
| SCHEMBL7769635 | 0.94 | ACP3 (0.47) | ACP3KCNH2SIGMAR1SLC6A4SLC6A2 | |
| Bromide SCHEMBL5510650 | 0.92 | ACP3 (0.46) | ACP3KCNH2SIGMAR1SLC6A4SLC6A2 | |
| SCHEMBL9132059 | 0.90 | ACP3 (0.44) | ACP3KCNH2SIGMAR1SLC6A4SLC6A2 | |
| SCHEMBL5076474 | 0.88 | ACP3 (0.47) | ACP3KCNH2SIGMAR1SLC6A4SLC6A2 | |
| SCHEMBL222542 | 0.88 | ACP3 (0.47) | ACP3KCNH2SIGMAR1SLC6A4SLC6A2 | |
| SCHEMBL197085 | 0.83 | KCNH2 (0.50) | KCNH2SIGMAR1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL15288212 | 0.82 | SIGMAR1 (0.49) | KCNH2SIGMAR1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9224540-B2 | Conductive polymer for solid electrolyte capacitor | SOLVAY USA, INC. (US) | 2015-12-29 | — | — | US | disclosed |
| EP-2855554-A2 | CONDUCTIVE POLYMER FOR SOLID ELECTROLYTIC CAPACITOR | Solvay USA Inc. (US) | 2015-04-08 | — | — | EP | disclosed |
| US-20140014881-A1 | CONDUCTIVE POLYMER FOR SOLID ELECTROLYTE CAPACITOR | PLEXTRONICS, INC. (US) | 2014-01-16 | — | — | US | disclosed |
| WO-2013181165-A2 | CONDUCTIVE POLYMER FOR SOLID ELECTROLYTIC CAPACITOR | PLEXTRONICS, INC. (US) | 2013-12-05 | — | — | WO | disclosed |