Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 2/20 | 0.46 |
| ▸ | CTSK | P43235 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA3 | P07451 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8271877 | 0.81 | CPA1 (0.51) | CTSSCTSKCA12CA1CA2 | |
| SCHEMBL8270567 | 0.78 | CA12 (0.49) | CTSSCTSKCA12CA1CA2 | |
| SCHEMBL23627513 | 0.77 | CHRNB2 (0.48) | CTSSCTSKCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL24642302 | 0.76 | CTSS (0.50) | CTSSCTSKCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL13626650 | 0.76 | CHRNB2 (0.54) | CTSSCTSKCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL18477610 | 0.75 | CTSS (0.49) | CTSSCTSKCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL6931278 | 0.74 | GNPAT (0.57) | CTSSCTSKCA12CA1CA2 | |
| SCHEMBL468905 | 0.74 | GNPAT (0.57) | CTSSCTSKCA12CA1CA2 | |
| SCHEMBL468907 | 0.74 | GNPAT (0.57) | CTSSCTSKCA12CA1CA2 | |
| SCHEMBL5125213 | 0.74 | HDAC1 (0.55) | CA1CA2CHRNB2CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2869820-A2 | PRODRUGS OF PEPTIDE EPOXY KETONE PROTEASE INHIBITORS | Onyx Therapeutics, Inc. (US) | 2015-05-13 | — | — | EP | disclosed |
| WO-2014011695-A2 | PRODRUGS OF PEPTIDE EPOXY KETONE PROTEASE INHIBITORS | ONYX THERAPEUTICS, INC. (US) | 2014-01-16 | — | — | WO | disclosed |