Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.37 |
| ▸ | CXCR2 | P25025 | 3/20 | 0.36 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23014011 | 0.75 | PTGER4 (0.55) | CXCR2CXCR1KMT2AMEN1MAPT | |
| SCHEMBL1006639 | 0.72 | GRIK1 (0.53) | CXCR2KMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL2554878 | 0.72 | RAB9A (0.54) | CXCR2KMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL17142280 | 0.69 | MAPT (0.46) | KMT2AMEN1MAPTNPC1LMNA | |
| SCHEMBL2429572 | 0.69 | RXFP1 (0.53) | KMT2AMEN1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL7135117 | 0.68 | MAPK1 (0.61) | KMT2AMEN1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL7001806 | 0.68 | RXFP1 (0.56) | CXCR2CXCR1MAPTNPC1LMNA | |
| SCHEMBL1978079 | 0.68 | RXFP1 (0.71) | KMT2AMEN1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL31053535 | 0.67 | L3MBTL1 (0.44) | KMT2AMEN1MAPTSMN1; SMN2LMNA | |
| SCHEMBL2436607 | 0.67 | L3MBTL1 (0.44) | KMT2AMEN1MAPTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2872514-A1 | IMIDAZOTRIAZINECARBONITRILES USEFUL AS KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2015-05-20 | — | — | EP | disclosed |
| WO-2014011974-A1 | IMIDAZOTRIAZINECARBONITRILES USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-01-16 | — | — | WO | disclosed |