SCHEMBL15415134

SCHEMBL15415134

O=C(O)CCOCCOCCOCCN1C(=O)C=C(Br)C1=O

nearest known ligand 0.42

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 1/20 0.42
RGS4 P49798 1/20 0.42
PTGS1 P23219 4/20 0.34
PTGS2 P35354 4/20 0.34
ALDH1A1 P00352 1/20 0.33
PKM P14618 1/20 0.33
DRD2 P14416 1/20 0.31
DRD3 P35462 1/20 0.31
MMP2 P08253 1/20 0.31
MMP9 P14780 1/20 0.31
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16283417 0.98 RGS4 (0.43) MGLLRGS4PTGS1PTGS2ALDH1A1
SCHEMBL19281082 0.85 RGS4 (0.35) RGS4ALDH1A1PKMSMN1; SMN2
SCHEMBL20574477 0.82 RGS4 (0.50) RGS4PTGS1PTGS2ALDH1A1PKM
SCHEMBL2724940 0.82 MGLL (0.42) MGLLPTGS1PTGS2ALDH1A1PKM
SCHEMBL15414992 0.80 ALDH1A1 (0.42) MGLLPTGS1PTGS2ALDH1A1PKM
SCHEMBL19280960 0.80 ALDH1A1 (0.42) MGLLPTGS1PTGS2ALDH1A1PKM
SCHEMBL15433009 0.79 MGLL (0.35) MGLLRGS4
SCHEMBL15433041 0.78 PTGS1 (0.57) RGS4PTGS1PTGS2ALDH1A1PKM
SCHEMBL15215618 0.78 MGLL (0.71) MGLLPTGS1PTGS2ALDH1A1PKM
SCHEMBL22311909 0.78 MGLL (0.71) MGLLPTGS1PTGS2ALDH1A1PKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11834406-B2 Conjugates of cell binding molecules with cytotoxic agents HANGZHOU DAC BIOTECH CO., LTD. (CN) 2023-12-05 US disclosed
US-11834406-B2 Conjugates of cell binding molecules with cytotoxic agents HANGZHOU DAC BIOTECH CO., LTD. (CN) 2023-12-05 US disclosed
US-11767294-B2 Conjugates of cell binding molecules with cytotoxic agents HANGZHOU DAC BIOTECH CO., LTD. (CN) 2023-09-26 US disclosed
EP-3210627-B1 CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS HANGZHOU DAC BIOTECH CO LTD (CN) 2022-12-21 EP disclosed
EP-2872157-B1 CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS HANGZHOU DAC BIOTECH CO LTD (CN) 2020-01-22 EP disclosed
US-20190330149-A1 CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS HANGZHOU DAC BIOTECH CO., LTD. (CN) 2019-10-31 US disclosed
US-10399941-B2 Conjugates of cell binding molecules with cytotoxic agents HANGZHOU DAC BIOTECH CO., LTD. (CN) 2019-09-03 US disclosed
EP-3348280-A1 CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS Hangzhou Dac Biotech Co., Ltd (CN) 2018-07-18 EP disclosed
US-20180021448-A9 Conjugates of Cell Binding Molecules with Cytotoxic Agents HANGZHOU DAC BIOTECH CO., LTD. (CN) 2018-01-25 US disclosed
US-20180021448-A9 Conjugates of Cell Binding Molecules with Cytotoxic Agents HANGZHOU DAC BIOTECH CO., LTD. (CN) 2018-01-25 US disclosed
US-20170296663-A1 Conjugates of Cell Binding Molecules with Cytotoxic Agents HANGZHOU DAC BIOTECH CO., LTD. (CN) 2017-10-19 US disclosed
US-20170296663-A1 Conjugates of Cell Binding Molecules with Cytotoxic Agents HANGZHOU DAC BIOTECH CO., LTD. (CN) 2017-10-19 US disclosed
EP-3210627-A1 CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS Hangzhou Dac Biotech Co., Ltd (CN) 2017-08-30 EP disclosed
US-20170157262-A1 CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS HANGZHOU DAC BIOTECH CO., LTD (CN) 2017-06-08 US disclosed
US-20170157262-A1 CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS HANGZHOU DAC BIOTECH CO., LTD (CN) 2017-06-08 US disclosed
EP-2872157-A1 CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS Hangzhou Dac Biotech Co., Ltd (CN) 2015-05-20 EP disclosed
WO-2014009774-A1 CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS HANGZHOU DAC BIOTECH CO., LTD (CN) 2014-01-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190330149-A1 CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS CD4, CD2, CD47 MGLL 3221/4885RGS4 2663/4885PTGS1 4300/4885
US-10399941-B2 Conjugates of cell binding molecules with cytotoxic agents CD4, CD2, CD47 MGLL 3221/4885RGS4 2663/4885PTGS1 4300/4885
US-20170157262-A1 CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS CD4, CD2, CD47 MGLL 3277/4885RGS4 2894/4885PTGS1 4563/4885
US-11767294-B2 Conjugates of cell binding molecules with cytotoxic agents CD4, CD2, CD47 MGLL 3221/4885RGS4 2663/4885PTGS1 4300/4885
US-20180021448-A9 Conjugates of Cell Binding Molecules with Cytotoxic Agents CD4, CD2, CD47 MGLL 3221/4885RGS4 2663/4885PTGS1 4300/4885
US-20170296663-A1 Conjugates of Cell Binding Molecules with Cytotoxic Agents CD4, CD2, CD47 MGLL 3221/4885RGS4 2663/4885PTGS1 4300/4885
US-11834406-B2 Conjugates of cell binding molecules with cytotoxic agents CD4, CD2, CD47 MGLL 3175/4885RGS4 2645/4885PTGS1 4442/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.