Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13629203 | 0.83 | NPC1 (0.50) | RAB9AKCNH2MEN1POLBGAA | |
| SCHEMBL15765651 | 0.78 | SLC6A2 (0.49) | P2RX7RAB9ADRD2DRD3HRH3 | |
| SCHEMBL18642219 | 0.76 | MAPT (0.50) | MEN1GAAKMT2ALMNAALDH1A1 | |
| SCHEMBL14894862 | 0.74 | HRH3 (0.37) | P2RX7HRH3ALDH1A1MAPT | |
| SCHEMBL24719495 | 0.73 | ALDH1A1 (0.48) | P2RX7MEN1KMT2ACYP3A4ALDH1A1 | |
| SCHEMBL25923495 | 0.73 | POLB (0.44) | RAB9AMEN1POLBKMT2ANPC1 | |
| SCHEMBL1583532 | 0.73 | P2RX7 (0.51) | P2RX7HRH3KCNH2CYP3A4LMNA | |
| SCHEMBL1709030 | 0.72 | MAPT (0.57) | RAB9AMEN1POLBKMT2ANPC1 | |
| SCHEMBL12615119 | 0.71 | RAB9A (0.51) | P2RX7RAB9ADRD2DRD3MEN1 | |
| SCHEMBL18805067 | 0.71 | RAB9A (0.51) | P2RX7RAB9ADRD2DRD3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2870140-A1 | TETRAHYDROQUINAZOLINONE DERIVATIVES AS PARP INHIBITORS | Lupin Limited (IN) | 2015-05-13 | — | — | EP | disclosed |
| WO-2014009872-A1 | TETRAHYDROQUINAZOLINONE DERIVATIVES AS PARP INHIBITORS | LUPIN LIMITED (IN) | 2014-01-16 | — | — | WO | disclosed |