Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1685314 | 0.83 | MEN1 (0.41) | MEN1KMT2ACYP3A4KDM4ESMN1; SMN2 | |
| SCHEMBL1282761 | 0.82 | PANK3 (0.45) | MEN1KMT2ACYP3A4KDM4E | |
| SCHEMBL22532812 | 0.81 | ALDH1A1 (0.62) | MEN1KMT2ACYP3A4CYP2C19KDM4E | |
| SCHEMBL15416130 | 0.81 | MEN1 (0.55) | MEN1KMT2ACYP3A4CYP2C19KDM4E | |
| SCHEMBL16797064 | 0.80 | MEN1 (0.38) | MEN1KMT2ACYP3A4CYP2C19KDM4E | |
| SCHEMBL21868482 | 0.79 | MEN1 (0.54) | MEN1KMT2ACYP3A4CYP2C19KDM4E | |
| SCHEMBL15416239 | 0.79 | MEN1 (0.54) | MEN1KMT2ACYP3A4CYP2C19KDM4E | |
| SCHEMBL28247431 | 0.79 | CYP3A4 (0.50) | MEN1KMT2ACYP3A4CYP2C19KDM4E | |
| SCHEMBL20565247 | 0.75 | HSD17B10 (0.47) | MEN1KMT2ACYP3A4CYP2C19KDM4E | |
| SCHEMBL1292596 | 0.75 | DGAT1 (0.38) | MEN1KMT2ACYP3A4CYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2872511-A1 | IMIDAZOPYRAZINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY | UCB Biopharma SPRL (BE) | 2015-05-20 | — | — | EP | disclosed |
| WO-2014009296-A1 | IMIDAZOPYRAZINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY | UCB PHARMA S.A. (BE) | 2014-01-16 | — | — | WO | disclosed |