Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1283028 | 0.84 | POLB (0.40) | MEN1KMT2ACYP3A4TSHR | |
| SCHEMBL2702106 | 0.81 | ALDH1A1 (0.49) | MEN1KMT2ACYP3A4KDM4ECYP2C19 | |
| SCHEMBL15416474 | 0.79 | MEN1 (0.58) | MEN1KMT2ACYP3A4KDM4ECYP2C19 | |
| SCHEMBL15416130 | 0.77 | MEN1 (0.55) | MEN1KMT2ACYP3A4KDM4ECYP2C19 | |
| SCHEMBL1292674 | 0.76 | RIPK1 (0.38) | MEN1KMT2A | |
| SCHEMBL21868482 | 0.76 | MEN1 (0.54) | MEN1KMT2ACYP3A4KDM4ECYP2C19 | |
| SCHEMBL6982738 | 0.75 | SORD (0.41) | — | |
| SCHEMBL1292392 | 0.73 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2MAPK1TDP1 | |
| SCHEMBL28247431 | 0.72 | CYP3A4 (0.50) | MEN1KMT2ACYP3A4KDM4ECYP2C19 | |
| SCHEMBL29516687 | 0.72 | SSTR5 (0.36) | CYP3A4CYP2C19ALDH1A1SMN1; SMN2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2872508-A1 | IMIDAZOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY | UCB Biopharma SPRL (BE) | 2015-05-20 | — | — | EP | disclosed |
| WO-2014009295-A1 | IMIDAZOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY | UCB PHARMA S.A. (BE) | 2014-01-16 | — | — | WO | disclosed |