Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.53 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | ALPL | P05186 | 2/20 | 0.51 |
| ▸ | ALPG | P10696 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15473947 | 0.88 | LMNA (0.61) | LMNACYP2C9CYP2C19GAAPTGS2 | |
| SCHEMBL20458926 | 0.88 | LMNA (0.58) | LMNACYP2C9CYP2C19GAAPTGS2 | |
| SCHEMBL13779968 | 0.87 | LMNA (0.67) | LMNAPTGS2KDM4ENPC1TDP1 | |
| SCHEMBL8601897 | 0.87 | NPSR1 (0.71) | LMNACYP2C19PTGS2KDM4ENPC1 | |
| SCHEMBL15471365 | 0.85 | LMNA (0.58) | LMNACYP2C9CYP2C19GAAPTGS2 | |
| SCHEMBL2876672 | 0.81 | KDM4E (0.60) | LMNAGAAKDM4ESMN1; SMN2HTT | |
| SCHEMBL13039592 | 0.79 | LMNA (0.60) | LMNAGAAPTGS2KDM4ENPC1 | |
| SCHEMBL1035783 | 0.78 | EGLN3 (0.71) | LMNACYP2C9CYP2C19PTGS2KDM4E | |
| SCHEMBL26935481 | 0.78 | HPGD (0.51) | LMNAPTGS2NPC1GRIN2BNPSR1 | |
| SCHEMBL15337854 | 0.78 | LMNA (0.53) | LMNACYP2C9CYP2C19GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2872502-A1 | NOVEL INDAZOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION | F. Hoffmann-La Roche AG (CH) | 2015-05-20 | — | — | EP | disclosed |
| WO-2014009302-A1 | NOVEL INDAZOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2014-01-16 | — | — | WO | disclosed |